(R)-2-Isopropoxy-succinic acid 1-benzyl ester 4-methyl ester

Base Information

• Chemical Name: (R)-2-Isopropoxy-succinic acid 1-benzyl ester 4-methyl ester
• CAS No.: 200866-91-7
• Molecular Formula: C₁₅H₂₀O₅
• Molecular Weight: 280.321
• Mol file: 200866-91-7.mol

Synonyms:(R)-2-Isopropoxy-succinic acid 1-benzyl ester 4-methyl ester

Chemical Property of (R)-2-Isopropoxy-succinic acid 1-benzyl ester 4-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-Isopropoxy-succinic acid 1-benzyl ester 4-methyl ester

There total 3 articles about (R)-2-Isopropoxy-succinic acid 1-benzyl ester 4-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

isopropyl bromide (75-26-3) + (R)-2-Hydroxy-succinic acid 1-benzyl ester 4-methyl ester (200866-90-6) → (R)-2-Isopropoxy-succinic acid 1-benzyl ester 4-methyl ester (200866-91-7)

Guidance literature:

With silver(l) oxide; at 50 ℃; for 48h;

DOI:10.1021/jm970494j

Reference yield:

1-O-methyl (3R)-3-hydroxysuccinate (109361-88-8) → (R)-2-Isopropoxy-succinic acid 1-benzyl ester 4-methyl ester (200866-91-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / K₂CO₃ / dimethylformamide / 1 h / Ambient temperature

2: 52 percent / Ag₂O / 48 h / 50 °C

With potassium carbonate; silver(l) oxide; In N,N-dimethyl-formamide;

DOI:10.1021/jm970494j

Reference yield:

methyl 2-((R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)acetate (200866-89-3) → (R)-2-Isopropoxy-succinic acid 1-benzyl ester 4-methyl ester (200866-91-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / 1 N HCl / tetrahydrofuran / 1 h / Ambient temperature

2: 58 percent / K₂CO₃ / dimethylformamide / 1 h / Ambient temperature

3: 52 percent / Ag₂O / 48 h / 50 °C

With hydrogenchloride; potassium carbonate; silver(l) oxide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm970494j

upstream raw materials:

isopropyl bromide

(R)-2-Hydroxy-succinic acid 1-benzyl ester 4-methyl ester

1-O-methyl (3R)-3-hydroxysuccinate

methyl 2-((R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)acetate