2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate

Base Information

• Chemical Name: 2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate
• CAS No.: 130914-74-8
• Molecular Formula: C₃₄H₄₃N₅O₁₀
• Molecular Weight: 681.743
• Mol file: 130914-74-8.mol

Synonyms:2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate

Chemical Property of 2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate

There total 5 articles about 2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

Cytosine (71-30-7) + 2-(methoxymethoxy)-1,3-propanediyl-bis-L-valinate> (170700-75-1) → 2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate (130914-74-8)

Guidance literature:

With benzenesulfonamide; t-butyldimethylsiyl triflate; In acetonitrile; for 18h; Heating;

DOI:10.1080/15257779508009494

Reference yield: 64.0%

(S)-N-(benzyloxycarbonyl)valine (1149-26-4) + 1-[[2-hydroxy-1-(hydroxy methyl)ethoxy]methyl]cytosine (87892-46-4) → N-(N-benzyloxycarbonyl-L-valyl)-N,N'-dicyclohexyl-urea (53111-06-1) + 2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate (130914-74-8) + (S)-2-Benzyloxycarbonylamino-3-methyl-butyric acid 2-[4-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-2-oxo-2H-pyrimidin-1-ylmethoxy]-3-((S)-2-benzyloxycarbonylamino-3-methyl-butyryloxy)-propyl ester

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 5 ℃; for 18h;

DOI:10.1080/15257779508009494

Reference yield:

2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methyloxy>-1,3-propanediyl dibenzoate (103824-50-6) → 2-<(4-amino-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl bis-L-valinate (130914-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / aq. MeNH₂ / 24 h / Ambient temperature

2: DCC, DMAP / dimethylformamide / 18 h / 5 °C

With dmap; dicyclohexyl-carbodiimide; methylamine; In N,N-dimethyl-formamide;

DOI:10.1080/15257779508009494

upstream raw materials:

(S)-N-(benzyloxycarbonyl)valine

1-[[2-hydroxy-1-(hydroxy methyl)ethoxy]methyl]cytosine

Cytosine

2-(methoxymethoxy)-1,3-propanediyl-bis-L-valinate>