benzyl (S)-(1-(2-cyano-1,2-dimethylhydrazinyl)-1-oxo-3-phenylpropan-2-yl)carbamate

Base Information

Chemical Name:benzyl (S)-(1-(2-cyano-1,2-dimethylhydrazinyl)-1-oxo-3-phenylpropan-2-yl)carbamate
CAS No.:1043922-53-7
Molecular Formula:C₂₀H₂₂N₄O₃
Molecular Weight:366.42
Hs Code.:

Synonyms:benzyl (S)-(1-(2-cyano-1,2-dimethylhydrazinyl)-1-oxo-3-phenylpropan-2-yl)carbamate

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Chemical Property of benzyl (S)-(1-(2-cyano-1,2-dimethylhydrazinyl)-1-oxo-3-phenylpropan-2-yl)carbamate

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Technology Process of benzyl (S)-(1-(2-cyano-1,2-dimethylhydrazinyl)-1-oxo-3-phenylpropan-2-yl)carbamate

There total 4 articles about benzyl (S)-(1-(2-cyano-1,2-dimethylhydrazinyl)-1-oxo-3-phenylpropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 506-68-3
bromocyane

: 1043922-50-4
(S)-benzyl (1-(1,2-dimethylhydrazinyl)-1-oxo-3-phenylpropan-2-yl)carbamate

: 1043922-53-7
benzyl (S)-(1-(2-cyano-1,2-dimethylhydrazinyl)-1-oxo-3-phenylpropan-2-yl)carbamate

Guidance literature:: With sodium acetate; In methanol; at 20 ℃; for 36h; Inert atmosphere;
DOI:10.1016/j.bmcl.2017.10.002

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 1043922-53-7
benzyl (S)-(1-(2-cyano-1,2-dimethylhydrazinyl)-1-oxo-3-phenylpropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -25 °C

2: sodium hydroxide / tetrahydrofuran; water / -25 - 20 °C

3: sodium acetate / methanol / 20 °C

With 4-methyl-morpholine; sodium acetate; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm101272p

Reference yield:

: 52641-32-4
N-benzyloxycarbonyl-L-phenylalanyl chloride

: 1043922-53-7
benzyl (S)-(1-(2-cyano-1,2-dimethylhydrazinyl)-1-oxo-3-phenylpropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran; water / -25 - 20 °C

2: sodium acetate / methanol / 20 °C

With sodium acetate; sodium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm101272p