- Chemical Name:Imidazo[1,2-b]pyridazine
- CAS No.:766-55-2
- Molecular Formula:C6H5N3
- Molecular Weight:119.126
- Hs Code.:29335990
- Mol file:766-55-2.mol
Synonyms:1,3a,4-Triazaindene;1,5-Diazaindolizine;
Synonyms:1,3a,4-Triazaindene;1,5-Diazaindolizine;
99% *data from raw suppliers
Imidazo[1,2]pyridazine *data from reagent suppliers
There total 6 articles about Imidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 100.0%
Reference yield: 87.0%
Reference yield:
This research endeavored to develop novel dual c-Met and VEGFR2 kinase inhibitors with potent antitumor efficacy against various human cancers. The study aimed to synthesize compounds that could inhibit both the c-mesenchymal epithelial transition factor (c-Met) and vascular endothelial growth factor receptor 2 (VEGFR2) kinases, which play significant roles in tumor growth, invasion, metastasis, and angiogenesis. Through structure-based design and synthesis, the researchers identified imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives, with particular emphasis on compound 26, an imidazo[1,2-a]pyridine derivative bearing a 6-methylpyridone ring. This compound strongly inhibited both c-Met and VEGFR2 enzyme activities, as well as the proliferation of c-Met-addicted MKN45 cells and VEGF-stimulated human umbilical vein endothelial cells (HUVEC), demonstrating dose-dependent antitumor efficacy in vivo in mouse xenograft models. The research concluded that compound 26 has promising therapeutic potential for the treatment of human cancers.