Methanesulfonic acid (2R,3S,4R,5R)-4-benzyloxy-5-benzyloxymethyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-2-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Methanesulfonic acid (2R,3S,4R,5R)-4-benzyloxy-5-benzyloxymethyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-2-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester
CAS No.:874812-38-1
Molecular Formula:C₄₂H₄₁N₃O₁₁S
Molecular Weight:795.867
Hs Code.:

Methanesulfonic acid (2R,3S,4R,5R)-4-benzyloxy-5-benzyloxymethyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-2-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester

Synonyms:Methanesulfonic acid (2R,3S,4R,5R)-4-benzyloxy-5-benzyloxymethyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-2-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester

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Chemical Property of Methanesulfonic acid (2R,3S,4R,5R)-4-benzyloxy-5-benzyloxymethyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-2-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester

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Technology Process of Methanesulfonic acid (2R,3S,4R,5R)-4-benzyloxy-5-benzyloxymethyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-2-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester

There total 8 articles about Methanesulfonic acid (2R,3S,4R,5R)-4-benzyloxy-5-benzyloxymethyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-2-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 874812-36-9
1-((2R,3S,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-3-hydroxy-2-hydroxymethyl-tetrahydro-furan-2-yl)-3-(4-methoxy-benzyl)-5-methyl-1H-pyrimidine-2,4-dione

: 1074-82-4
potassium phtalimide

: 124-63-0
methanesulfonyl chloride

: Methanesulfonic acid (2R,3S,4R,5R)-4-benzyloxy-5-benzyloxymethyl-2-hydroxymethyl-2-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester

: 874812-38-1
Methanesulfonic acid (2R,3S,4R,5R)-4-benzyloxy-5-benzyloxymethyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-2-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester

Guidance literature:: 1-((2R,3S,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-3-hydroxy-2-hydroxymethyl-tetrahydro-furan-2-yl)-3-(4-methoxy-benzyl)-5-methyl-1H-pyrimidine-2,4-dione; methanesulfonyl chloride; With pyridine; at 0 - 4 ℃;

potassium phtalimide; In N,N-dimethyl-formamide; at 110 ℃;
DOI:10.1021/jo052115x

Reference yield:

: 1054657-53-2
(2R,3R,3aS,9aR)-3-Benzyloxy-2-benzyloxymethyl-9a-hydroxymethyl-7-methyl-2,3,3a,9a-tetrahydro-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one

: 874812-38-1
Methanesulfonic acid (2R,3S,4R,5R)-4-benzyloxy-5-benzyloxymethyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-2-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3.26 g / aq. NaOH / ethanol / 20 °C

2.1: 98 percent / pyridine / 3 h / 20 °C

3.1: 80 percent / NaH / dimethylformamide / 0 - 20 °C

4.1: 94 percent / MeONa / methanol / 0.5 h / 20 °C

5.1: pyridine / 0 - 4 °C

5.2: 77 percent / dimethylformamide / 110 °C

With pyridine; sodium hydroxide; sodium methylate; sodium hydride; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo052115x

Reference yield:

: 874812-33-6
1-((2R,3S,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-3-hydroxy-2-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

: 874812-38-1
Methanesulfonic acid (2R,3S,4R,5R)-4-benzyloxy-5-benzyloxymethyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-2-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / pyridine / 3 h / 20 °C

2.1: 80 percent / NaH / dimethylformamide / 0 - 20 °C

3.1: 94 percent / MeONa / methanol / 0.5 h / 20 °C

4.1: pyridine / 0 - 4 °C

4.2: 77 percent / dimethylformamide / 110 °C

With pyridine; sodium methylate; sodium hydride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo052115x