N-[(S)-1-(1,4-Dithia-spiro[4.5]dec-6-ylcarbamoyl)-2-phenyl-ethyl]-succinamic acid methyl ester

Base Information

Chemical Name:N-[(S)-1-(1,4-Dithia-spiro[4.5]dec-6-ylcarbamoyl)-2-phenyl-ethyl]-succinamic acid methyl ester
CAS No.:189947-55-5
Molecular Formula:C₂₂H₃₀N₂O₄S₂
Molecular Weight:450.623
Hs Code.:

Synonyms:N-[(S)-1-(1,4-Dithia-spiro[4.5]dec-6-ylcarbamoyl)-2-phenyl-ethyl]-succinamic acid methyl ester

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Chemical Property of N-[(S)-1-(1,4-Dithia-spiro[4.5]dec-6-ylcarbamoyl)-2-phenyl-ethyl]-succinamic acid methyl ester

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Technology Process of N-[(S)-1-(1,4-Dithia-spiro[4.5]dec-6-ylcarbamoyl)-2-phenyl-ethyl]-succinamic acid methyl ester

There total 3 articles about N-[(S)-1-(1,4-Dithia-spiro[4.5]dec-6-ylcarbamoyl)-2-phenyl-ethyl]-succinamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130858-97-8
N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl fluoride

: 189947-55-5
N-[(S)-1-(1,4-Dithia-spiro[4.5]dec-6-ylcarbamoyl)-2-phenyl-ethyl]-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DIEA

2: N(CH₂CH₂NH₂)3 / CH₂Cl₂

3: HOBT, EDC / CH₂Cl₂ / Ambient temperature

With 2,2',2''-triaminotriethylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ja9641867

Reference yield:

: 189947-51-1
[(S)-1-(1,4-Dithia-spiro[4.5]dec-6-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

: 189947-55-5
N-[(S)-1-(1,4-Dithia-spiro[4.5]dec-6-ylcarbamoyl)-2-phenyl-ethyl]-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N(CH₂CH₂NH₂)3 / CH₂Cl₂

2: HOBT, EDC / CH₂Cl₂ / Ambient temperature

With 2,2',2''-triaminotriethylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1021/ja9641867

Reference yield:

: 3878-55-5
methyl hydrogen succinate

: (S)-2-Amino-N-(1,4-dithia-spiro[4.5]dec-6-yl)-3-phenyl-propionamide

: 189947-55-5
N-[(S)-1-(1,4-Dithia-spiro[4.5]dec-6-ylcarbamoyl)-2-phenyl-ethyl]-succinamic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; Yield given; Ambient temperature;
DOI:10.1021/ja9641867