Technology Process of 6-(2-Hydroxy-ethyl)-3,4-dimethoxy-2-nitro-benzoic acid benzyl ester
There total 8 articles about 6-(2-Hydroxy-ethyl)-3,4-dimethoxy-2-nitro-benzoic acid benzyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 77 percent / NO2BF4 / tetrahydrothiophene 1,1-dioxide
2: 100 percent / aq. LiOH / tetrahydrofuran
3: (COCl)2, DMF / benzene
4: diethyl ether
5: 76 percent / silver benzoate, TEA
6: 100 percent / aq. LiOH / tetrahydrofuran
7: 1.) BH3*THF, 2.) aq. LiOH / 1.) THF, 2.) THF
8: NaHCO3, TBAI / dimethylformamide
With
lithium hydroxide; nitronium tetrafluoborate; borane-THF; oxalyl dichloride; TEA; silver benzoate; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; N,N-dimethyl-formamide;
In
tetrahydrofuran; sulfolane; diethyl ether; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00068a087
- Guidance literature:
-
Multi-step reaction with 6 steps
1: (COCl)2, DMF / benzene
2: diethyl ether
3: 76 percent / silver benzoate, TEA
4: 100 percent / aq. LiOH / tetrahydrofuran
5: 1.) BH3*THF, 2.) aq. LiOH / 1.) THF, 2.) THF
6: NaHCO3, TBAI / dimethylformamide
With
lithium hydroxide; borane-THF; oxalyl dichloride; TEA; silver benzoate; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; N,N-dimethyl-formamide;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00068a087
- Guidance literature:
-
Multi-step reaction with 5 steps
1: diethyl ether
2: 76 percent / silver benzoate, TEA
3: 100 percent / aq. LiOH / tetrahydrofuran
4: 1.) BH3*THF, 2.) aq. LiOH / 1.) THF, 2.) THF
5: NaHCO3, TBAI / dimethylformamide
With
lithium hydroxide; borane-THF; TEA; silver benzoate; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/ja00068a087