6-chloro-1-oxo-2-pentyl-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid

Base Information

Chemical Name:6-chloro-1-oxo-2-pentyl-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid
CAS No.:1332697-16-1
Molecular Formula:C₂₁H₂₀ClNO₃
Molecular Weight:369.848
Hs Code.:

Synonyms:6-chloro-1-oxo-2-pentyl-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid

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Chemical Property of 6-chloro-1-oxo-2-pentyl-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid

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Technology Process of 6-chloro-1-oxo-2-pentyl-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid

There total 6 articles about 6-chloro-1-oxo-2-pentyl-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₂ClNO₄

: 1332697-16-1
6-chloro-1-oxo-2-pentyl-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: C₂₁H₁₉ClO₇

: 1332697-16-1
6-chloro-1-oxo-2-pentyl-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water; acetic acid / 3 h / 110 °C

2: methanol / 15 h / 20 °C

3: hydrogenchloride / ethyl acetate / 3 h / 20 °C

With hydrogenchloride; water; acetic acid; In methanol; ethyl acetate;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: 118-45-6
4-chlorophthalic anhydride

: 1332697-16-1
6-chloro-1-oxo-2-pentyl-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / 40 h / 0 - 20 °C

1.2: 0 °C

2.1: potassium carbonate / N,N-dimethyl-formamide; acetone / 1.5 h / 20 °C

3.1: hydrogenchloride; water; acetic acid / 3 h / 110 °C

4.1: methanol / 15 h / 20 °C

5.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

With hydrogenchloride; aluminum (III) chloride; water; potassium carbonate; acetic acid; In methanol; ethyl acetate; N,N-dimethyl-formamide; acetone; 1.1: Friedel-Crafts acylation;
DOI:10.1016/j.bmc.2011.06.059