(1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-6-[cyclopropyl-(2,3-dichloro-benzyl)-carbamoyl]-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid 3-tert-butyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

Base Information

Chemical Name:(1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-6-[cyclopropyl-(2,3-dichloro-benzyl)-carbamoyl]-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid 3-tert-butyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester
CAS No.:1149624-87-2
Molecular Formula:C₄₃H₅₈Cl₅N₃O₆Si
Molecular Weight:918.301
Hs Code.:

(1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-6-[cyclopropyl-(2,3-dichloro-benzyl)-carbamoyl]-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid 3-tert-butyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

Synonyms:(1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-6-[cyclopropyl-(2,3-dichloro-benzyl)-carbamoyl]-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid 3-tert-butyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

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Chemical Property of (1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-6-[cyclopropyl-(2,3-dichloro-benzyl)-carbamoyl]-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid 3-tert-butyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

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Technology Process of (1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-6-[cyclopropyl-(2,3-dichloro-benzyl)-carbamoyl]-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid 3-tert-butyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

There total 1 articles about (1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-6-[cyclopropyl-(2,3-dichloro-benzyl)-carbamoyl]-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid 3-tert-butyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 625437-42-5
cyclopropyl-(2,3-dichlorobenzyl)amine

: 1149624-78-1
(1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3-tert-butyl ester 6-ethyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: (1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-6-[cyclopropyl-(2,3-dichloro-benzyl)-carbamoyl]-3,9-diaza-bicyclo[3.3.1]non-7-ene-3,9-dicarboxylic acid 3-tert-butyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

: 1149624-87-2
(1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-6-[cyclopropyl-(2,3-dichloro-benzyl)-carbamoyl]-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid 3-tert-butyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

Guidance literature:: (1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3-tert-butyl ester 6-ethyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester; With ethanol; water; sodium hydroxide; at 80 ℃; for 12h;

tert-butyldimethylsilyl chloride; With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

cyclopropyl-(2,3-dichlorobenzyl)amine; Further stages;
DOI:10.1021/jm900022f

Reference yield:

: 1149624-87-2
(1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-6-[cyclopropyl-(2,3-dichloro-benzyl)-carbamoyl]-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid 3-tert-butyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

: C₃₂H₃₆Cl₅N₃O₄

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 3.33333h; Inert atmosphere;
DOI:10.1021/jm900022f