(1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3-tert-butyl ester 6-ethyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

Base Information

Chemical Name:(1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3-tert-butyl ester 6-ethyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester
CAS No.:1149624-78-1
Molecular Formula:C₃₅H₅₃Cl₃N₂O₇Si
Molecular Weight:748.26
Hs Code.:

(1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3-tert-butyl ester 6-ethyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

Synonyms:(1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3-tert-butyl ester 6-ethyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

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Chemical Property of (1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3-tert-butyl ester 6-ethyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

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Technology Process of (1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3-tert-butyl ester 6-ethyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

There total 1 articles about (1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3-tert-butyl ester 6-ethyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 66270-36-8
2,2,2-trichloro-1,1-dimethylethoxychloroformate

: 1149624-76-9
(1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-9-methyl-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6-dicarboxylic acid 3-tert-butyl ester 6-ethyl ester

: 1149624-78-1
(1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3-tert-butyl ester 6-ethyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

Guidance literature:: With sodium hydrogencarbonate; In 1,2-dichloro-ethane; at 80 ℃; Inert atmosphere;
DOI:10.1021/jm900022f

Reference yield:

: 1149624-78-1
(1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3-tert-butyl ester 6-ethyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1149624-84-9
(1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-7-ene-3,6,9-tricarboxylic acid 3-tert-butyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

: 1149624-83-8
(1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3-tert-butyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

Guidance literature:: (1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3-tert-butyl ester 6-ethyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester; With ethanol; water; sodium hydroxide; at 80 ℃; for 12h;

tert-butyldimethylsilyl chloride; With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

With methanol; water; potassium carbonate; In tetrahydrofuran; at 20 ℃; for 1.5h;
DOI:10.1021/jm900022f

Reference yield:

: 1149624-78-1
(1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3-tert-butyl ester 6-ethyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: C₃₉H₆₃Cl₃N₂O₇Si₂

: C₃₉H₆₃Cl₃N₂O₇Si₂

Guidance literature:: (1R,5S)-7-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenyl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6,9-tricarboxylic acid 3-tert-butyl ester 6-ethyl ester 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester; With ethanol; water; sodium hydroxide; at 80 ℃; for 12h;

tert-butyldimethylsilyl chloride; With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm900022f