methyl N-cyano-N-cyclohexylaminoacetate

Base Information

• Chemical Name: methyl N-cyano-N-cyclohexylaminoacetate
• CAS No.: 1034186-46-3
• Molecular Formula: C₁₀H₁₆N₂O₂
• Molecular Weight: 196.249
• Mol file: 1034186-46-3.mol

Synonyms:methyl N-cyano-N-cyclohexylaminoacetate

Chemical Property of methyl N-cyano-N-cyclohexylaminoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N-cyano-N-cyclohexylaminoacetate

There total 2 articles about methyl N-cyano-N-cyclohexylaminoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-cyanocyclohexylamine (4421-48-1) + bromoacetic acid methyl ester (96-32-2) → methyl N-cyano-N-cyclohexylaminoacetate (1034186-46-3)

Guidance literature:

N-cyanocyclohexylamine; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h; Inert atmosphere;

bromoacetic acid methyl ester; In tetrahydrofuran; mineral oil; at 0 ℃; for 2h;

DOI:10.1002/ejoc.200701025

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) → methyl N-cyano-N-cyclohexylaminoacetate (1034186-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: sodium hydride / mineral oil; tetrahydrofuran

With sodium hydride; In tetrahydrofuran; diethyl ether; mineral oil;

DOI:10.1016/j.tetlet.2012.09.057

Reference yield: 92.0%

methyl N-cyano-N-cyclohexylaminoacetate (1034186-46-3) → 1-cyclohexylhydantoin (6777-06-6)

Guidance literature:

With dibutyl phosphate; at 100 ℃; for 1h; Neat (no solvent);

DOI:10.1016/j.tetlet.2011.09.029

upstream raw materials:

N-cyanocyclohexylamine

bromoacetic acid methyl ester

cyclohexylamine

Downstream raw materials:

1-cyclohexylhydantoin

1-cyclohexylthiohydantoin

Refernces

• 1、 Kumar, Vinod,Kaushik,Mazumdar, Avik. "An efficient approach for the synthesis of N-1 substituted hydantoins". experimental part. p. 1910 - 1916. Retrieved 2009/04/04.