5-[1-(3-Fluoro-2-methoxy-phenyl)-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one

Base Information

• Chemical Name: 5-[1-(3-Fluoro-2-methoxy-phenyl)-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one
• CAS No.: 796087-21-3
• Molecular Formula: C₁₁H₈FNO₂S₂
• Molecular Weight: 269.32
• Mol file: 796087-21-3.mol

Synonyms:5-[1-(3-Fluoro-2-methoxy-phenyl)-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one

Chemical Property of 5-[1-(3-Fluoro-2-methoxy-phenyl)-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[1-(3-Fluoro-2-methoxy-phenyl)-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one

There total 2 articles about 5-[1-(3-Fluoro-2-methoxy-phenyl)-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-thioxo-4-thiazolidinone (141-84-4) + fluoro-3 methoxy-2 benzaldehhyde (74266-68-5) → 5-[1-(3-Fluoro-2-methoxy-phenyl)-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one (796087-21-3)

Guidance literature:

With ammonium acetate; In toluene;

DOI:10.1016/j.bmcl.2004.08.005

Reference yield:

3-fluorosalicylaldehyde (394-50-3) → 5-[1-(3-Fluoro-2-methoxy-phenyl)-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one (796087-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / K₂CO₃ / acetone

2: 78 percent / H₄NOAc / toluene

With ammonium acetate; potassium carbonate; In acetone; toluene;

DOI:10.1016/j.bmcl.2004.08.005

Reference yield: 94.0%

5-[1-(3-Fluoro-2-methoxy-phenyl)-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one (796087-21-3) → (2Z)-3-(3-fluoro-2-methoxyphenyl)-2-mercapto-2-propenoic acid (476198-90-0)

Guidance literature:

With sodium hydroxide;

DOI:10.1016/j.bmcl.2004.08.005

upstream raw materials:

2-thioxo-4-thiazolidinone

fluoro-3 methoxy-2 benzaldehhyde

3-fluorosalicylaldehyde

Downstream raw materials:

(2Z)-3-(3-fluoro-2-methoxyphenyl)-2-mercapto-2-propenoic acid

5-fluoro-4-hydroxybenzothiophene

5-fluoro-4-methoxybenzothiophenecarboxylic acid

4-(3-chloro-1-phenyl-propoxy)-5-fluoro-benzo[b]thiophene