4-<3-<4--1-piperidinyl>propoxy>benzeneacetic acid

Base Information

Chemical Name:4-<3-<4--1-piperidinyl>propoxy>benzeneacetic acid
CAS No.:117023-76-4
Molecular Formula:C₂₉H₃₁F₂NO₄
Molecular Weight:495.566
Hs Code.:

4-<3-<4-<bis(4-fluorophenyl)hydroxymethyl>-1-piperidinyl>propoxy>benzeneacetic acid

Synonyms:4-<3-<4--1-piperidinyl>propoxy>benzeneacetic acid

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Chemical Property of 4-<3-<4--1-piperidinyl>propoxy>benzeneacetic acid

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Technology Process of 4-<3-<4--1-piperidinyl>propoxy>benzeneacetic acid

There total 7 articles about 4-<3-<4--1-piperidinyl>propoxy>benzeneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 117023-74-2
[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-acetic acid methyl ester

: 117023-76-4
4-<3-<4--1-piperidinyl>propoxy>benzeneacetic acid

Guidance literature:: With potassium hydroxide; In ethanol; water; for 1.5h; Heating;
DOI:10.1021/jm00121a022

Reference yield:

: 24228-40-8
N-benzyl isonipecotic acid ethyl ester

: 117023-76-4
4-<3-<4--1-piperidinyl>propoxy>benzeneacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 43 percent / Na₂CO₃, KI / dimethylformamide / Heating

4: 78 percent / KOH / H₂O; aq. ethanol / 1.5 h / Heating

With potassium hydroxide; hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00121a022

Reference yield:

: 111627-25-9
α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol

: 117023-76-4
4-<3-<4--1-piperidinyl>propoxy>benzeneacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

2: 43 percent / Na₂CO₃, KI / dimethylformamide / Heating

3: 78 percent / KOH / H₂O; aq. ethanol / 1.5 h / Heating

With potassium hydroxide; hydrogen; sodium carbonate; potassium iodide; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00121a022