111627-25-9

Basic information

• Product Name: α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol
• Synonyms: α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol
• CAS NO: 111627-25-9
• Molecular Weight: 393.476
• Mol File: 111627-25-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol(111627-25-9)
• EPA Substance Registry System: α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol(111627-25-9)

Safety Data

• Hazardous Substances Data: 111627-25-9(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 1126-09-6 4-carbethoxypiperidine 
• 24228-40-8 N-benzyl isonipecotic acid ethyl ester 
• 352-13-6 4-flourophenylmagnesium bromide 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 93076-09-6 4-[bis(4-fluorophenyl)methylene]-1-(phenylmethyl)piperidine 
• 117023-36-6 α,α-bis(4-fluorophenyl)-1-[3-[2-(phenylmethoxy)phenoxy]propyl]-4-piperidinemethanol 
• 117023-77-5 3-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-propionic acid methyl ester 
• 117023-74-2 [4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-acetic acid methyl ester 
• 117023-00-4 Bis-(4-fluoro-phenyl)-{1-[3-(2-phenyl-[1,3]dioxolan-2-yl)-propyl]-piperidin-4-yl}-methanol 
• 117023-66-2 4-<3-<4--1-piperidinyl>propoxy>benzoic acid methyl ester 
• 117023-80-0 1-<3-(4-aminophenoxy)propyl>-α,α-bis(4-fluorophenyl)-4-piperidinemethanol 
• 117023-04-8 4--α-phenyl-1-piperidinebutanol 
• 117023-02-6 4-<4--1-piperidinyl>-1-phenyl-1-butanone 
• 117023-85-5 <<4-<3-<4--1-piperidinyl>propoxy>phenyl>amino>oxoacetic acid ethyl ester (E)-2-butenedioate (2:1) 
• 117023-88-8 N-<4-<3-<4--1-piperidinyl>propoxy>phenyl>methanesulfonamide (E)-2-butenedioate (2:1) 
• 117023-83-3 [4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-carbamic acid ethyl ester; compound with oxalic acid 
• 117023-73-1 4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-N,N-dimethyl-benzamide; compound with (E)-but-2-enedioic acid 
• 111626-84-7 α,α-[Bis(4-fluorophenyl)]-1-[3-[4-(methylsulfonyl)phenoxy]propyl]-4-piperidinemethanol fumarate 

Relevant articles and documents

SYNTHESIS OF 4-(NITROBENZYL- AND BENZOYL)PIPERIDINE DERIVATIVES BY NITRATION OF ARYLALKYLPIPERIDINES

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Arylalkylheterocyclic amines,N-substituted by aryloxyalkyl group in a method for allergy treatment

A method of inhibiting Type 1 allergic responses in a living animal body with substituted heterocyclic amines is disclosed wherein the active agents are expressed generally by the formula which includes certain known and certain known compounds: STR1 wherein P is zero, one or two; m is one to six inclusive; A is selected from hydrogen, hydroxy or cyano; d is zero or one; Q is --CH--, CH2 -- or STR2 n is zero or one and when Q is --CH-- and n is one, a double bond is formed with one of the adjacent carbons but not both at the same time, and when n and d are zero at the same time, a double bond is formed between the α carbon and a carbon of the central heterocyclic amine ring; Ar, D and R are selected from phenyl, substituted phenyl, pyridinyl, thienyl, furanyl or naphthyl and in addition, R may have the values benzyl, substituted benzyl, cycloalkyl or loweralkyl and D may additionally have the values: 2H-1-benzopyran-2-one,4-oxo-4H-1-benzopyran-2-carboxylic acid loweralkyl ester, 2,3-dihydro-4H-1-benzopyran-4-one, 1,4-benzodioxanloweralkyl-2-yl or 1,1'-biphenyl-4-yl and the pharmaceutically acceptable salts thereof.

4-[(α,α-diaryl)-hydroxymethyl]-1-piperidinylalkyl-cyclic carbamate derivatives as allergic response inhibitors

4-[(α,α-Diaryl)-hydroxymethyl]-1-piperidinylalkylcyclic carbamate derivatives having the formula: STR1 wherein; R is hydrogen, loweralkyl, cycloalkyl, phenyl and substituted phenyl; Ar and Ar1 are phenyl, substituted phenyl or pyridinyl; alk is a straight or branched hydrocarbon chain; R1 is loweralkyl substituted for hydrogen on a ring carbon. The compounds are useful antihistamines and in controlling allergic response.