C₄₂H₄₅N₃O₈S₂Si

Base Information

• Chemical Name: C₄₂H₄₅N₃O₈S₂Si
• CAS No.: 1571067-39-4
• Molecular Formula: C₄₂H₄₅N₃O₈S₂Si
• Molecular Weight: 812.052
• Mol file: 1571067-39-4.mol

Synonyms:C₄₂H₄₅N₃O₈S₂Si

Chemical Property of C₄₂H₄₅N₃O₈S₂Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₂H₄₅N₃O₈S₂Si

There total 7 articles about C₄₂H₄₅N₃O₈S₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 3-((tert-butyldimethylsilyl)oxy)-1-carbamoyl-2,4-bis-(1-tosyl-1H-indol-3-yl)cyclobutane-1-carboxylate (1571067-33-8) → C42H45N3O8S2Si (1571067-39-4)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jo4027148

Reference yield:

methyl 3-hydroxy-1-(4-methoxyphenyl)cyclobutane-1-carboxylate → C42H45N3O8S2Si (1571067-39-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 1H-imidazole / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.1: sodium periodate; ruthenium(IV) oxide hydrate / water; ethyl acetate / 14 h / 4 - 20 °C / Inert atmosphere

3.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 15 h / 0 - 20 °C / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 4 °C / Inert atmosphere

5.1: silver pivalate / toluene / 24 h / 120 °C / Sealed tube; Inert atmosphere

5.2: 24 h / 20 °C / Inert atmosphere

6.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With 1H-imidazole; sodium periodate; ruthenium(IV) oxide hydrate; lithium hydroxide monohydrate; potassium tert-butylate; silver pivalate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene;

DOI:10.1021/jo4027148

Reference yield:

C12H14O4 (1353636-86-8) → C42H45N3O8S2Si (1571067-39-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sulfuric acid / 12 h / 60 °C / Inert atmosphere

2.1: 1H-imidazole / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.1: sodium periodate; ruthenium(IV) oxide hydrate / water; ethyl acetate / 14 h / 4 - 20 °C / Inert atmosphere

4.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 15 h / 0 - 20 °C / Inert atmosphere

5.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 4 °C / Inert atmosphere

6.1: silver pivalate / toluene / 24 h / 120 °C / Sealed tube; Inert atmosphere

6.2: 24 h / 20 °C / Inert atmosphere

7.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With 1H-imidazole; sodium periodate; ruthenium(IV) oxide hydrate; lithium hydroxide monohydrate; sulfuric acid; potassium tert-butylate; silver pivalate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene; 1.1: |Fischer-Speier Esterification;

DOI:10.1021/jo4027148

upstream raw materials:

C₁₂H₁₄O₄

methyl 3-((tert-butyldimethylsilyl)oxy)-1-carbamoyl-2,4-bis-(1-tosyl-1H-indol-3-yl)cyclobutane-1-carboxylate

Downstream raw materials:

1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carbonitrile

2-((tert-butyldimethylsilyl)oxy)-1,3-bis(1-tosyl-1H-indol-3-yl)-5,7-diazaspiro[3.4]octane-6,8-dione