2-((tert-butyldimethylsilyl)oxy)-1,3-bis(1-tosyl-1H-indol-3-yl)-5,7-diazaspiro[3.4]octane-6,8-dione

Base Information

• Chemical Name: 2-((tert-butyldimethylsilyl)oxy)-1,3-bis(1-tosyl-1H-indol-3-yl)-5,7-diazaspiro[3.4]octane-6,8-dione
• CAS No.: 1571067-41-8
• Molecular Formula: C₄₂H₄₄N₄O₇S₂Si
• Molecular Weight: 809.051

Synonyms:2-((tert-butyldimethylsilyl)oxy)-1,3-bis(1-tosyl-1H-indol-3-yl)-5,7-diazaspiro[3.4]octane-6,8-dione

Chemical Property of 2-((tert-butyldimethylsilyl)oxy)-1,3-bis(1-tosyl-1H-indol-3-yl)-5,7-diazaspiro[3.4]octane-6,8-dione

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Technology Process of 2-((tert-butyldimethylsilyl)oxy)-1,3-bis(1-tosyl-1H-indol-3-yl)-5,7-diazaspiro[3.4]octane-6,8-dione

There total 1 articles about 2-((tert-butyldimethylsilyl)oxy)-1,3-bis(1-tosyl-1H-indol-3-yl)-5,7-diazaspiro[3.4]octane-6,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

C42H45N3O8S2Si (1571067-39-4) → 1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carbonitrile (1571067-40-7) + 2-((tert-butyldimethylsilyl)oxy)-1,3-bis(1-tosyl-1H-indol-3-yl)-5,7-diazaspiro[3.4]octane-6,8-dione (1571067-41-8)

Guidance literature:

With diphenylphosphoranyl azide; triethylamine; In dichloromethane; at 0 - 50 ℃; for 30h; Inert atmosphere;

DOI:10.1021/jo4027148

Reference yield: 80.0%

2-((tert-butyldimethylsilyl)oxy)-1,3-bis(1-tosyl-1H-indol-3-yl)-5,7-diazaspiro[3.4]octane-6,8-dione (1571067-41-8) + methyl iodide (74-88-4) → 2-((tert-butyldimethylsilyl)oxy)-5,7-dimethyl-1,3-bis(1-tosyl-1H-indol-3-yl)-5,7-diazaspiro[3.4]octane-6,8-dione (1571067-42-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo4027148

upstream raw materials:

C₄₂H₄₅N₃O₈S₂Si

Downstream raw materials:

2-((tert-butyldimethylsilyl)oxy)-5,7-dimethyl-1,3-bis(1-tosyl-1H-indol-3-yl)-5,7-diazaspiro[3.4]octane-6,8-dione

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