7-Ethyl-3-(4-methoxy-phenyl)-4-oxo-4,7-dihydro-isothiazolo[5,4-b]pyridine-5-carboxylic acid

Base Information

• Chemical Name: 7-Ethyl-3-(4-methoxy-phenyl)-4-oxo-4,7-dihydro-isothiazolo[5,4-b]pyridine-5-carboxylic acid
• CAS No.: 75907-66-3
• Molecular Formula: C₁₆H₁₄N₂O₄S
• Molecular Weight: 330.364

Synonyms:7-Ethyl-3-(4-methoxy-phenyl)-4-oxo-4,7-dihydro-isothiazolo[5,4-b]pyridine-5-carboxylic acid

Chemical Property of 7-Ethyl-3-(4-methoxy-phenyl)-4-oxo-4,7-dihydro-isothiazolo[5,4-b]pyridine-5-carboxylic acid

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Technology Process of 7-Ethyl-3-(4-methoxy-phenyl)-4-oxo-4,7-dihydro-isothiazolo[5,4-b]pyridine-5-carboxylic acid

There total 4 articles about 7-Ethyl-3-(4-methoxy-phenyl)-4-oxo-4,7-dihydro-isothiazolo[5,4-b]pyridine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-Hydroxy-3-(4-methoxy-phenyl)-isothiazolo[5,4-b]pyridine-5-carboxylic acid (75907-63-0) + ethyl iodide (75-03-6) → 7-Ethyl-3-(4-methoxy-phenyl)-4-oxo-4,7-dihydro-isothiazolo[5,4-b]pyridine-5-carboxylic acid (75907-66-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 - 80 ℃; for 4h;

DOI:10.1002/jhet.5570170418

Reference yield:

3-(p-methoxyphenyl)-5-aminothiazole (75907-55-0) → 7-Ethyl-3-(4-methoxy-phenyl)-4-oxo-4,7-dihydro-isothiazolo[5,4-b]pyridine-5-carboxylic acid (75907-66-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent / 1 h / 110 °C

2: 78 percent / diphenyl ether / 0.75 h / Heating

3: 59 percent / 10percent NaOH / ethanol / 1 h / Heating

4: 58 percent / potassium carbonate / dimethylformamide / 4 h / 70 - 80 °C

With sodium hydroxide; potassium carbonate; In diphenylether; ethanol; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570170418

Reference yield:

4-Hydroxy-3-(4-methoxy-phenyl)-isothiazolo[5,4-b]pyridine-5-carboxylic acid ethyl ester (75907-60-7) → 7-Ethyl-3-(4-methoxy-phenyl)-4-oxo-4,7-dihydro-isothiazolo[5,4-b]pyridine-5-carboxylic acid (75907-66-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / 10percent NaOH / ethanol / 1 h / Heating

2: 58 percent / potassium carbonate / dimethylformamide / 4 h / 70 - 80 °C

With sodium hydroxide; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570170418

upstream raw materials:

4-Hydroxy-3-(4-methoxy-phenyl)-isothiazolo[5,4-b]pyridine-5-carboxylic acid

ethyl iodide

3-(p-methoxyphenyl)-5-aminothiazole

4-Hydroxy-3-(4-methoxy-phenyl)-isothiazolo[5,4-b]pyridine-5-carboxylic acid ethyl ester

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