C₂₃H₂₄F₂O₃

Base Information

• Chemical Name: C₂₃H₂₄F₂O₃
• CAS No.: 1403326-75-9
• Molecular Formula: C₂₃H₂₄F₂O₃
• Molecular Weight: 386.439
• Mol file: 1403326-75-9.mol

Synonyms:C₂₃H₂₄F₂O₃

Chemical Property of C₂₃H₂₄F₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₄F₂O₃

There total 12 articles about C₂₃H₂₄F₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methyl 2,6-difluoro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate (1403326-91-9) → C23H24F2O3 (1403326-75-9)

Guidance literature:

With water; potassium hydroxide; In methanol; at 85 ℃; for 1h;

DOI:10.1002/cmdc.201200319

Reference yield:

3,5-difluorobenzoic acid (455-40-3) → C23H24F2O3 (1403326-75-9)

Guidance literature:

Multi-step reaction with 9 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.5 h / -78 °C

1.2: 18 h / -78 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h

2.2: 5 h / 20 °C

3.1: aminosulfonic acid; sodium chlorite / water; acetonitrile / 1 h / 20 °C

4.1: thionyl chloride / 1 h / 84 °C

5.1: triethylamine / toluene / 1.17 h / 20 °C

6.1: hydrogen; 10% Pd/C / ethyl acetate; ethanol / 48 h / 20 °C

7.1: thionyl chloride / 1 h / 85 °C

8.1: aluminum (III) chloride / dichloromethane / 0.33 h / 20 °C / Reflux

9.1: water; potassium hydroxide / methanol / 1 h / 85 °C

With aluminum (III) chloride; sodium chlorite; thionyl chloride; 10% Pd/C; aminosulfonic acid; water; hydrogen; tert.-butyl lithium; sodium hydride; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil; pentane;

DOI:10.1002/cmdc.201200319

Reference yield:

benzyl-3,5-difluoro-4-formylbenzoate (1403326-80-6) → C23H24F2O3 (1403326-75-9)

Guidance literature:

Multi-step reaction with 7 steps

1: aminosulfonic acid; sodium chlorite / water; acetonitrile / 1 h / 20 °C

2: thionyl chloride / 1 h / 84 °C

3: triethylamine / toluene / 1.17 h / 20 °C

4: hydrogen; 10% Pd/C / ethyl acetate; ethanol / 48 h / 20 °C

5: thionyl chloride / 1 h / 85 °C

6: aluminum (III) chloride / dichloromethane / 0.33 h / 20 °C / Reflux

7: water; potassium hydroxide / methanol / 1 h / 85 °C

With aluminum (III) chloride; sodium chlorite; thionyl chloride; 10% Pd/C; aminosulfonic acid; water; hydrogen; triethylamine; potassium hydroxide; In methanol; ethanol; dichloromethane; water; ethyl acetate; toluene; acetonitrile;

DOI:10.1002/cmdc.201200319

upstream raw materials:

3,5-difluoro-4-formylbenzoic acid

3,5-difluorobenzoic acid

benzyl-3,5-difluoro-4-formylbenzoate

4-((benzyloxy)carbonyl)-2,6-difluorobenzoic acid