[4-(1,1-dioxo-1λ⁶-isothiazolidin-2-yl)phenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanone

Base Information

• Chemical Name: [4-(1,1-dioxo-1λ⁶-isothiazolidin-2-yl)phenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanone
• CAS No.: 1346115-10-3
• Molecular Formula: C₂₃H₂₆N₂O₄S
• Molecular Weight: 426.536

Synonyms:[4-(1,1-dioxo-1λ⁶-isothiazolidin-2-yl)phenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanone

Chemical Property of [4-(1,1-dioxo-1λ⁶-isothiazolidin-2-yl)phenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanone

Chemical Property:

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Technology Process of [4-(1,1-dioxo-1λ⁶-isothiazolidin-2-yl)phenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanone

There total 2 articles about [4-(1,1-dioxo-1λ⁶-isothiazolidin-2-yl)phenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)benzoic acid (52962-52-4) + (piperidin-4-yl)(p-tolyl)methanone hydrochloride (42060-84-4) → [4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanone (1346115-10-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

p-aminoethylbenzoate (94-09-7) → [4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanone (1346115-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 20 °C / Cooling with ice

1.2: 3 h / 20 °C

2.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

p-aminoethylbenzoate

4-(1,1-dioxo-1λ⁶-isothiazolidin-2-yl)benzoic acid

(piperidin-4-yl)(p-tolyl)methanone hydrochloride

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