3-[2-(2-Chloro-2-cyclohexyl-acetylamino)-3-trifluoromethyl-phenyl]-3-oxo-N-thiazol-2-yl-propionamide

Base Information

Chemical Name:3-[2-(2-Chloro-2-cyclohexyl-acetylamino)-3-trifluoromethyl-phenyl]-3-oxo-N-thiazol-2-yl-propionamide
CAS No.:114351-33-6
Molecular Formula:C₂₁H₂₁ClF₃N₃O₃S
Molecular Weight:487.93
Hs Code.:

Synonyms:3-[2-(2-Chloro-2-cyclohexyl-acetylamino)-3-trifluoromethyl-phenyl]-3-oxo-N-thiazol-2-yl-propionamide

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Chemical Property of 3-[2-(2-Chloro-2-cyclohexyl-acetylamino)-3-trifluoromethyl-phenyl]-3-oxo-N-thiazol-2-yl-propionamide

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Technology Process of 3-[2-(2-Chloro-2-cyclohexyl-acetylamino)-3-trifluoromethyl-phenyl]-3-oxo-N-thiazol-2-yl-propionamide

There total 4 articles about 3-[2-(2-Chloro-2-cyclohexyl-acetylamino)-3-trifluoromethyl-phenyl]-3-oxo-N-thiazol-2-yl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 313-12-2
2-amino-3-(trifluoromethyl)benzoic acid

: 114351-33-6
3-[2-(2-Chloro-2-cyclohexyl-acetylamino)-3-trifluoromethyl-phenyl]-3-oxo-N-thiazol-2-yl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / N-methylmorpholine / CH₂Cl₂ / 20 h / Ambient temperature

2: 1.) butyllithium / 1) THF, 0 deg C; 2) -75 deg C, THF

With 4-methyl-morpholine; n-butyllithium; In dichloromethane;
DOI:10.1021/jm00402a034

Reference yield:

: 35468-15-6
(cyclohexyl)chloroacetic acid

: 114351-33-6
3-[2-(2-Chloro-2-cyclohexyl-acetylamino)-3-trifluoromethyl-phenyl]-3-oxo-N-thiazol-2-yl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-methylmorpholine, isobutyl chloroformate / CH₂Cl₂ / 0.5 h / -20 °C

2: 77 percent / N-methylmorpholine / CH₂Cl₂ / 20 h / Ambient temperature

3: 1.) butyllithium / 1) THF, 0 deg C; 2) -75 deg C, THF

With 4-methyl-morpholine; n-butyllithium; isobutyl chloroformate; In dichloromethane;
DOI:10.1021/jm00402a034

Reference yield:

: Chloro-cyclohexyl-acetyl chloride

: 114351-33-6
3-[2-(2-Chloro-2-cyclohexyl-acetylamino)-3-trifluoromethyl-phenyl]-3-oxo-N-thiazol-2-yl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / N-methylmorpholine / CH₂Cl₂ / 20 h / Ambient temperature

2: 1.) butyllithium / 1) THF, 0 deg C; 2) -75 deg C, THF

With 4-methyl-morpholine; n-butyllithium; In dichloromethane;
DOI:10.1021/jm00402a034