2-(Chloro-cyclohexyl-methyl)-8-trifluoromethyl-benzo[d][1,3]oxazin-4-one

Base Information

Chemical Name:2-(Chloro-cyclohexyl-methyl)-8-trifluoromethyl-benzo[d][1,3]oxazin-4-one
CAS No.:114351-25-6
Molecular Formula:C₁₆H₁₅ClF₃NO₂
Molecular Weight:345.749
Hs Code.:

Synonyms:2-(Chloro-cyclohexyl-methyl)-8-trifluoromethyl-benzo[d][1,3]oxazin-4-one

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Chemical Property of 2-(Chloro-cyclohexyl-methyl)-8-trifluoromethyl-benzo[d][1,3]oxazin-4-one

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Technology Process of 2-(Chloro-cyclohexyl-methyl)-8-trifluoromethyl-benzo[d][1,3]oxazin-4-one

There total 2 articles about 2-(Chloro-cyclohexyl-methyl)-8-trifluoromethyl-benzo[d][1,3]oxazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 313-12-2
2-amino-3-(trifluoromethyl)benzoic acid

: Chloro-cyclohexyl-acetyl chloride

: 114351-25-6
2-(Chloro-cyclohexyl-methyl)-8-trifluoromethyl-benzo[d][1,3]oxazin-4-one

Guidance literature:: With 4-methyl-morpholine; In dichloromethane; for 20h; Ambient temperature;
DOI:10.1021/jm00402a034

Reference yield:

: 35468-15-6
(cyclohexyl)chloroacetic acid

: 114351-25-6
2-(Chloro-cyclohexyl-methyl)-8-trifluoromethyl-benzo[d][1,3]oxazin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: N-methylmorpholine, isobutyl chloroformate / CH₂Cl₂ / 0.5 h / -20 °C

2: 77 percent / N-methylmorpholine / CH₂Cl₂ / 20 h / Ambient temperature

With 4-methyl-morpholine; isobutyl chloroformate; In dichloromethane;
DOI:10.1021/jm00402a034

Reference yield:

: 114351-25-6
2-(Chloro-cyclohexyl-methyl)-8-trifluoromethyl-benzo[d][1,3]oxazin-4-one

: 114351-44-9
3-Cyclohexyl-1-[(Z)-thiazol-2-ylimino]-5-trifluoromethyl-1,3-dihydro-furo[3,4-b]quinolin-9-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) butyllithium / 1) THF, 0 deg C; 2) -75 deg C, THF

2: 100 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 16 h / Heating

With dmap; n-butyllithium; In tetrahydrofuran;
DOI:10.1021/jm00402a034