ethyl 2-[3-(4-methylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]acetate

Base Information

• Chemical Name: ethyl 2-[3-(4-methylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]acetate
• CAS No.: 58112-51-9
• Molecular Formula: C₁₅H₁₈N₂O₃
• Molecular Weight: 274.32
• Mol file: 58112-51-9.mol

Synonyms:ethyl 2-[3-(4-methylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]acetate

Chemical Property of ethyl 2-[3-(4-methylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[3-(4-methylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]acetate

There total 7 articles about ethyl 2-[3-(4-methylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-(4-methylbenzoyl)propionic acid (4619-20-9) + 2-hydrazinyl acetic acid ethyl ester hydrochloride (6945-92-2) → ethyl 2-[3-(4-methylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]acetate (58112-51-9)

Guidance literature:

With TEA; In ethanol; Heating;

Reference yield: 72.0%

6-(4-methylphenyl)-4,5-dihydro-3(2H)-pyridazinone (1079-72-7) + chloroacetic acid ethyl ester (105-39-5) → ethyl 2-[3-(4-methylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]acetate (58112-51-9)

Guidance literature:

6-(4-methylphenyl)-4,5-dihydro-3(2H)-pyridazinone; With sodium; In ethanol; for 0.5h; Reflux;

chloroacetic acid ethyl ester; In ethanol; for 24h; Reflux;

DOI:10.1007/s00044-013-0618-0

Reference yield: 28.0%

hydrazinoacetic acid ethyl ester hydrochloride + 3-(4-methylbenzoyl)propionic acid (4619-20-9) → ethyl 2-[3-(4-methylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]acetate (58112-51-9)

Guidance literature:

With triethylamine; In ethanol; for 6h; Reflux;

upstream raw materials:

3-(4-methylbenzoyl)propionic acid

2-hydrazinyl acetic acid ethyl ester hydrochloride

6-(4-methylphenyl)-4,5-dihydro-3(2H)-pyridazinone

ethyl bromoacetate

Downstream raw materials:

2-[6-oxo-3-(p-tolyl)-4,5-dihydropyridazin-1-yl]acetic acid

2-(6-oxo-3-p-tolyl-5,6-dihydropyridazin-1(4H)-yl)acetohydrazide