2-[E-3-(N,N-dimethylamino)acryloyl]-3-methyl-5,6-diphenylimidazo[2,1-b]thiazole

Base Information

• Chemical Name: 2-[E-3-(N,N-dimethylamino)acryloyl]-3-methyl-5,6-diphenylimidazo[2,1-b]thiazole
• CAS No.: 1403659-86-8
• Molecular Formula: C₂₃H₂₁N₃OS
• Molecular Weight: 387.505

Synonyms:2-[E-3-(N,N-dimethylamino)acryloyl]-3-methyl-5,6-diphenylimidazo[2,1-b]thiazole

Chemical Property of 2-[E-3-(N,N-dimethylamino)acryloyl]-3-methyl-5,6-diphenylimidazo[2,1-b]thiazole

Chemical Property:

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Technology Process of 2-[E-3-(N,N-dimethylamino)acryloyl]-3-methyl-5,6-diphenylimidazo[2,1-b]thiazole

There total 3 articles about 2-[E-3-(N,N-dimethylamino)acryloyl]-3-methyl-5,6-diphenylimidazo[2,1-b]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + 2-acetyl-3-methyl-5,6-diphenylimidazo[2,1-b]thiazole (28466-09-3) → 2-[E-3-(N,N-dimethylamino)acryloyl]-3-methyl-5,6-diphenylimidazo[2,1-b]thiazole (1403659-86-8)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; for 3h; Reflux;

DOI:10.3987/COM-12-12531

Reference yield:

acetylacetone (123-54-6,81235-32-7) → 2-[E-3-(N,N-dimethylamino)acryloyl]-3-methyl-5,6-diphenylimidazo[2,1-b]thiazole (1403659-86-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; acetic acid / Enzymatic reaction

2: 5,5-dimethyl-1,3-cyclohexadiene / 3 h / Reflux

With sulfuric acid; acetic acid; In 5,5-dimethyl-1,3-cyclohexadiene;

DOI:10.3987/COM-12-12531

Reference yield:

4,5-diphenyl-1H-imidazole-2-thiol (2349-58-8) → 2-[E-3-(N,N-dimethylamino)acryloyl]-3-methyl-5,6-diphenylimidazo[2,1-b]thiazole (1403659-86-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; acetic acid / Enzymatic reaction

2: 5,5-dimethyl-1,3-cyclohexadiene / 3 h / Reflux

With sulfuric acid; acetic acid; In 5,5-dimethyl-1,3-cyclohexadiene;

DOI:10.3987/COM-12-12531

upstream raw materials:

acetylacetone

N,N-dimethyl-formamide dimethyl acetal

2-acetyl-3-methyl-5,6-diphenylimidazo[2,1-b]thiazole

4,5-diphenyl-1H-imidazole-2-thiol

Downstream raw materials:

3-methyl-2-(7-methyl-2-phenyl-2H-pyrazolo[3,4-d]pyridazin-4-yl)-5,6-diphenylimidazo[2,1-b]thiazole

2-(2,7-diphenyl-2H-pyrazolo[3,4-d]pyridazin-4-yl)-3-methyl-5,6-diphenylimidazo[2,1-b]thiazole

3-methyl-5,6-diphenyl-2-(1H-pyrazol-3-yl)imidazo[2,1-b]thiazole

2-(3-isoxazolyl)-3-methyl-5,6-diphenylimidazo[2,1-b]thiazole

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