4-Fluoro-2-nitroanisole

Base Information

• Chemical Name: 4-Fluoro-2-nitroanisole
• CAS No.: 445-83-0
• Molecular Formula: C7H6FNO3
• Molecular Weight: 171.128
• Hs Code.: 29093090
• Mol file: 445-83-0.mol

Synonyms:4-FLUORO-1-METHOXY-2-NITROBENZENE;4-FLUORO-2-NITROANISOLE;4-Fluoro-2-nitro-methoxybenzene;4-Fluoro-2-nitroanisole 98%;4-Fluoro-2-nitroanisole98%;1-Methoxy-2-nitro-4-fluorobenzene;4-Fluoro-2-nitroanis

Chemical Property of 4-Fluoro-2-nitroanisole

Chemical Property:

• Vapor Pressure: 0.0102mmHg at 25°C
• Melting Point: 62-64 °C(lit.)
• Refractive Index: 1.521
• Boiling Point: 272.4 °C at 760 mmHg
• Flash Point: 118.5 °C
• PSA: 55.05000
• Density: 1.321 g/cm³
• LogP: 2.26570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: soluble in Toluene

Purity/Quality:

98% ^*data from raw suppliers

4-Fluoro-2-nitroanisole >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluoro-2-nitroanisole

There total 12 articles about 4-Fluoro-2-nitroanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-nitro-4-fluorophenol (394-33-2) + methyl iodide (74-88-4) → 4-fluoro-1-methoxy-2-nitrobenzene (445-83-0)

Guidance literature:

With potassium carbonate; In acetonitrile; for 15h; Heating / reflux;

Reference yield: 78.8%

1-fluoro-4-methoxybenzene (459-60-9) → 2-nitro-4-fluorophenol (394-33-2) + 4-fluoro-1-methoxy-2-nitrobenzene (445-83-0)

Guidance literature:

With nitric acid; In sulfuric acid; at 25 ℃; Rate constant; Product distribution; various acid concentrations;

DOI:10.1039/P29830000075

Reference yield: 6.0%

1-fluoro-4-methoxybenzene (459-60-9) → 4-fluoro-1-methoxy-2-nitrobenzene (445-83-0) + 4-fluoro-4-nitrocyclohexa-2,5-dienone (123871-59-0)

Guidance literature:

With nitric acid; In acetic anhydride; at -60 ℃; for 0.0125h;

upstream raw materials:

1-fluoro-4-methoxybenzene

diazomethane

2-nitro-4-fluorophenol

tetranitromethane

Downstream raw materials:

2-nitro-4-fluorophenol

5-fluoro-2-methoxy-aniline

4-fluoro-2-nitroso-anisole

4-hydroxy-2-nitroanisole

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