methyl 3(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate

Base Information

Chemical Name:methyl 3(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate
CAS No.:146349-40-8
Molecular Formula:C₂₂H₂₉N₃O₆
Molecular Weight:431.489
Hs Code.:

Synonyms:methyl 3(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate

Suppliers and Price of methyl 3(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 3(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 3(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate

There total 4 articles about methyl 3(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28957-33-7
(R)-3-amino-azepan-2-one

: 146349-40-8
methyl 3(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 85.6 percent / Et₃N / H₂O; dioxane / 18 h / Ambient temperature

2: 1.) NaH / 1.) THF, 30 min, 2.) THF, a) 4 deg C, 4 h, b) RT, 12 h

3: 98.9 percent / 4 N HCl / dioxane / 1.5 h

4: Et₃N / tetrahydrofuran; dimethylformamide / a) -20 deg C, 2 h, b) RT, 2 h

With hydrogenchloride; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00054a010

Reference yield:

: 106691-72-9
3(R)--2-oxoperhydroazepine

: 146349-40-8
methyl 3(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, 30 min, 2.) THF, a) 4 deg C, 4 h, b) RT, 12 h

2: 98.9 percent / 4 N HCl / dioxane / 1.5 h

3: Et₃N / tetrahydrofuran; dimethylformamide / a) -20 deg C, 2 h, b) RT, 2 h

With hydrogenchloride; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00054a010

Reference yield:

: 82611-53-8
methyl 3(R)--2-oxo-1-perhydroazepineacetate

: 146349-40-8
methyl 3(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 98.9 percent / 4 N HCl / dioxane / 1.5 h

2: Et₃N / tetrahydrofuran; dimethylformamide / a) -20 deg C, 2 h, b) RT, 2 h

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00054a010