6-Amino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid [(1S,2S)-1-cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propyl]-amide

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Chemical Name:6-Amino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid [(1S,2S)-1-cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propyl]-amide
CAS No.:138643-22-8
Molecular Formula:C₄₇H₅₉N₅O₅
Molecular Weight:774.016
Hs Code.:

6-Amino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid [(1S,2S)-1-cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propyl]-amide

Synonyms:6-Amino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid [(1S,2S)-1-cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propyl]-amide

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Chemical Property of 6-Amino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid [(1S,2S)-1-cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propyl]-amide

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Technology Process of 6-Amino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid [(1S,2S)-1-cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propyl]-amide

There total 3 articles about 6-Amino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid [(1S,2S)-1-cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132125-36-1
[5-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propylcarbamoyl]-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pent-2-ynyl]-carbamic acid tert-butyl ester

: 138643-22-8
6-Amino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid [(1S,2S)-1-cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propyl]-amide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; Ambient temperature;
DOI:10.1021/jm00108a004

Reference yield:

: 124278-65-5
(S,S)-γ-amino-β-hydroxy-N-<2-(4-morpholinyl)ethyl>cyclohexane pentanamide

: 138643-22-8
6-Amino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid [(1S,2S)-1-cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / 1.) DMF, 0 deg C, 10 min, 2.) a) 0 deg C, 1 h, b) RT

2: trifluoroacetic acid (TFA) / CH₂Cl₂ / Ambient temperature

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00108a004

Reference yield:

: 138643-21-7
6-tert-Butoxycarbonylamino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid

: 138643-22-8
6-Amino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid [(1S,2S)-1-cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / 1.) DMF, 0 deg C, 10 min, 2.) a) 0 deg C, 1 h, b) RT

2: trifluoroacetic acid (TFA) / CH₂Cl₂ / Ambient temperature

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00108a004