[5-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propylcarbamoyl]-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pent-2-ynyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [5-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propylcarbamoyl]-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pent-2-ynyl]-carbamic acid tert-butyl ester
• CAS No.: 132125-36-1
• Molecular Formula: C₅₂H₆₇N₅O₇
• Molecular Weight: 874.133
• Mol file: 132125-36-1.mol

Synonyms:

Chemical Property of [5-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propylcarbamoyl]-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pent-2-ynyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [5-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propylcarbamoyl]-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pent-2-ynyl]-carbamic acid tert-butyl ester

There total 1 articles about [5-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propylcarbamoyl]-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pent-2-ynyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S,S)-γ-amino-β-hydroxy-N-<2-(4-morpholinyl)ethyl>cyclohexane pentanamide (124278-65-5) + 6-tert-Butoxycarbonylamino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid (138643-21-7) → [5-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propylcarbamoyl]-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pent-2-ynyl]-carbamic acid tert-butyl ester (132125-36-1)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) DMF, 0 deg C, 10 min, 2.) a) 0 deg C, 1 h, b) RT;

DOI:10.1021/jm00108a004

Reference yield:

[5-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propylcarbamoyl]-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pent-2-ynyl]-carbamic acid tert-butyl ester (132125-36-1) → 6-Amino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid [(1S,2S)-1-cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propyl]-amide (138643-22-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00108a004

Reference yield:

[5-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propylcarbamoyl]-5-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-pent-2-ynyl]-carbamic acid tert-butyl ester (132125-36-1) → C48H60N8O7 (132101-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid (TFA) / CH₂Cl₂ / Ambient temperature

2: CH₂Cl₂ / 6 h / 25 °C

With trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm00108a004

upstream raw materials:

(S,S)-γ-amino-β-hydroxy-N-<2-(4-morpholinyl)ethyl>cyclohexane pentanamide

6-tert-Butoxycarbonylamino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid

Downstream raw materials:

6-Amino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid [(1S,2S)-1-cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propyl]-amide

6-Formylamino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid [(1S,2S)-1-cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propyl]-amide

6-Acetylamino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid [(1S,2S)-1-cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propyl]-amide

6-(3-Methyl-thioureido)-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hex-4-ynoic acid [(1S,2S)-1-cyclohexylmethyl-2-hydroxy-3-(2-morpholin-4-yl-ethylcarbamoyl)-propyl]-amide