N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-2,2-dimethyl-3-phenylpropanamide

Base Information

Chemical Name:N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-2,2-dimethyl-3-phenylpropanamide
CAS No.:1623774-85-5
Molecular Formula:C₂₃H₂₈N₄O
Molecular Weight:376.502
Hs Code.:

Synonyms:N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-2,2-dimethyl-3-phenylpropanamide

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Chemical Property of N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-2,2-dimethyl-3-phenylpropanamide

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Technology Process of N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-2,2-dimethyl-3-phenylpropanamide

There total 4 articles about N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-2,2-dimethyl-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1310826-33-5
2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-amine

: 62931-24-2
2,2-dimethyl-3-phenylpropanoyl chloride

: 1623774-85-5
N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-2,2-dimethyl-3-phenylpropanamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere; Schlenk technique;
DOI:10.1002/anie.201311024

Reference yield:

: 622-79-7
benzyl azide

: 1623774-85-5
N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-2,2-dimethyl-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 20 °C / Inert atmosphere; Schlenk technique

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere; Schlenk technique

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; triethylamine; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/anie.201311024

Reference yield:

: 2978-58-7
1,1-dimethylprop-3-ynylamine

: 1623774-85-5
N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-2,2-dimethyl-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 20 °C / Inert atmosphere; Schlenk technique

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere; Schlenk technique

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; triethylamine; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/anie.201311024