1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1,2-pyrrolidinedicarboxylate

Base Information

Chemical Name:1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1,2-pyrrolidinedicarboxylate
CAS No.:1195787-75-7
Molecular Formula:C₃₆H₃₈F₇N₃O₅
Molecular Weight:725.704
Hs Code.:

1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1,2-pyrrolidinedicarboxylate

Synonyms:1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1,2-pyrrolidinedicarboxylate

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Chemical Property of 1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1,2-pyrrolidinedicarboxylate

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Technology Process of 1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1,2-pyrrolidinedicarboxylate

There total 5 articles about 1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1,2-pyrrolidinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1195787-73-5
methyl (5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-L-prolinate

: 1195787-75-7
1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1,2-pyrrolidinedicarboxylate

Guidance literature:: In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 23235-01-0
(2S)-2-amino-4-pentynoic acid

: 1195787-75-7
1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1,2-pyrrolidinedicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 0 - 20 °C

2.1: sodium hydrogencarbonate / 1,4-dioxane; water / 3 h / 20 °C

3.1: copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine / bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 100 °C / Microwave irradiation

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.2: 20 °C

5.1: sodium tetrahydroborate / methanol / 2 h / 0 °C

6.1: dichloromethane / 1 h / 20 °C

With sodium tetrahydroborate; copper(l) iodide; thionyl chloride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 101925-55-7
(S)-propargylglycine methyl ester

: 1195787-75-7
1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1,2-pyrrolidinedicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane; water / 3 h / 20 °C

2.1: copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine / bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 100 °C / Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.2: 20 °C

4.1: sodium tetrahydroborate / methanol / 2 h / 0 °C

5.1: dichloromethane / 1 h / 20 °C

With sodium tetrahydroborate; copper(l) iodide; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; methanol; dichloromethane; water;