methyl (5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-L-prolinate

Base Information

Chemical Name:methyl (5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-L-prolinate
CAS No.:1195787-73-5
Molecular Formula:C₃₁H₃₀F₇N₃O₃
Molecular Weight:625.586
Hs Code.:

Synonyms:methyl (5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-L-prolinate

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Chemical Property of methyl (5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-L-prolinate

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Technology Process of methyl (5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-L-prolinate

There total 5 articles about methyl (5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-L-prolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.92%

: 1195787-70-2
methyl (2S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3,4-dihydro-2H-pyrrole-2-carboxylate

: 1195787-71-3
methyl (5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-L-prolinate

: 1195787-73-5
methyl (5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-L-prolinate

Guidance literature:: methyl (2S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3,4-dihydro-2H-pyrrole-2-carboxylate; With sodium tetrahydroborate; In methanol; at 0 ℃; for 2h;

With sodium hydrogencarbonate; In methanol; Saturated solution;

Reference yield:

: 23235-01-0
(2S)-2-amino-4-pentynoic acid

: 1195787-73-5
methyl (5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-L-prolinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 0 - 20 °C

2.1: sodium hydrogencarbonate / 1,4-dioxane; water / 3 h / 20 °C

3.1: copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine / bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 100 °C / Microwave irradiation

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.2: 20 °C

5.1: sodium tetrahydroborate / methanol / 2 h / 0 °C

With sodium tetrahydroborate; copper(l) iodide; thionyl chloride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 101925-55-7
(S)-propargylglycine methyl ester

: 1195787-73-5
methyl (5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-L-prolinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane; water / 3 h / 20 °C

2.1: copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine / bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 100 °C / Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.2: 20 °C

4.1: sodium tetrahydroborate / methanol / 2 h / 0 °C

With sodium tetrahydroborate; copper(l) iodide; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; methanol; dichloromethane; water;