3-(2-bromophenoxy)-2'-fluoro-4'-(methoxymethyl)biphenyl-2-carbonitrile

Base Information

Chemical Name:3-(2-bromophenoxy)-2'-fluoro-4'-(methoxymethyl)biphenyl-2-carbonitrile
CAS No.:1416858-10-0
Molecular Formula:C₂₁H₁₅BrFNO₂
Molecular Weight:412.258
Hs Code.:

Synonyms:3-(2-bromophenoxy)-2'-fluoro-4'-(methoxymethyl)biphenyl-2-carbonitrile

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Chemical Property of 3-(2-bromophenoxy)-2'-fluoro-4'-(methoxymethyl)biphenyl-2-carbonitrile

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Technology Process of 3-(2-bromophenoxy)-2'-fluoro-4'-(methoxymethyl)biphenyl-2-carbonitrile

There total 5 articles about 3-(2-bromophenoxy)-2'-fluoro-4'-(methoxymethyl)biphenyl-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1416858-09-7
3-(2-bromophenoxy)-2'-fluoro-4'-(hydroxymethyl)biphenyl-2-carbonitrile

: 74-88-4
methyl iodide

: 1416858-10-0
3-(2-bromophenoxy)-2'-fluoro-4'-(methoxymethyl)biphenyl-2-carbonitrile

Guidance literature:: 3-(2-bromophenoxy)-2'-fluoro-4'-(hydroxymethyl)biphenyl-2-carbonitrile; With sodium hydride; In tetrahydrofuran; Pionier 2076; at 17 - 25 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; Pionier 2076; for 2h;

Reference yield:

: 79544-27-7
2-bromo-6-fluorobenzonitrile

: 1416858-10-0
3-(2-bromophenoxy)-2'-fluoro-4'-(methoxymethyl)biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 100 °C

3.1: sodium tetrahydroborate / methanol / 0.5 h

4.1: sodium hydride / tetrahydrofuran; Pionier 2076 / 0.5 h / 17 - 25 °C

4.2: 2 h

With potassium fluoride; sodium tetrahydroborate; sodium hydride; potassium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; methanol; Pionier 2076; N,N-dimethyl-formamide;

Reference yield:

: 871126-22-6
(2-fluoro-4-formylphenyl)boronic acid

: 1416858-10-0
3-(2-bromophenoxy)-2'-fluoro-4'-(methoxymethyl)biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 100 °C

3.1: sodium tetrahydroborate / methanol / 0.5 h

4.1: sodium hydride / tetrahydrofuran; Pionier 2076 / 0.5 h / 17 - 25 °C

4.2: 2 h

With potassium fluoride; sodium tetrahydroborate; sodium hydride; potassium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; methanol; Pionier 2076; N,N-dimethyl-formamide;