(2S,2'S)-diethyl 2,2'-((4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenyl)phosphoryl)bis(azanediyl)dipropanoate

Base Information

Chemical Name:(2S,2'S)-diethyl 2,2'-((4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenyl)phosphoryl)bis(azanediyl)dipropanoate
CAS No.:1428526-14-0
Molecular Formula:C₃₄H₃₉N₆O₈P
Molecular Weight:690.693
Hs Code.:

(2S,2'S)-diethyl 2,2'-((4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenyl)phosphoryl)bis(azanediyl)dipropanoate

Synonyms:(2S,2'S)-diethyl 2,2'-((4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenyl)phosphoryl)bis(azanediyl)dipropanoate

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Chemical Property of (2S,2'S)-diethyl 2,2'-((4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenyl)phosphoryl)bis(azanediyl)dipropanoate

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Technology Process of (2S,2'S)-diethyl 2,2'-((4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenyl)phosphoryl)bis(azanediyl)dipropanoate

There total 11 articles about (2S,2'S)-diethyl 2,2'-((4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenyl)phosphoryl)bis(azanediyl)dipropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1428526-13-9
4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonic acid

: 1115-59-9
(S)-alanine ethyl ester hydrochloride

: 1428526-14-0
(2S,2'S)-diethyl 2,2'-((4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenyl)phosphoryl)bis(azanediyl)dipropanoate

Guidance literature:: With 2,2'-dipyridyldisulphide; triethylamine; triphenylphosphine; In pyridine; at 85 ℃;

Reference yield:

: 56406-45-2
4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxylic acid

: 1428526-14-0
(2S,2'S)-diethyl 2,2'-((4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenyl)phosphoryl)bis(azanediyl)dipropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / 1-methyl-pyrrolidin-2-one / 0.25 h / 20 °C

1.2: 1 h / 70 °C

1.3: 0.5 h / 70 °C

2.1: trimethylsilyl bromide / dichloromethane / 0 - 20 °C

3.1: 2,2'-dipyridyldisulphide; triethylamine; triphenylphosphine / pyridine / 85 °C

With 2,2'-dipyridyldisulphide; trimethylsilyl bromide; triethylamine; triphenylphosphine; In pyridine; 1-methyl-pyrrolidin-2-one; dichloromethane;

Reference yield:

: 1428526-11-7
diethyl 4-(amino(4-methoxyphenyl)methyl)phenylphosphonate

: 1428526-14-0
(2S,2'S)-diethyl 2,2'-((4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenyl)phosphoryl)bis(azanediyl)dipropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / 1-methyl-pyrrolidin-2-one / 0.25 h / 20 °C

1.2: 1 h / 70 °C

1.3: 0.5 h / 70 °C

2.1: trimethylsilyl bromide / dichloromethane / 0 - 20 °C

3.1: 2,2'-dipyridyldisulphide; triethylamine; triphenylphosphine / pyridine / 85 °C

With 2,2'-dipyridyldisulphide; trimethylsilyl bromide; triethylamine; triphenylphosphine; In pyridine; 1-methyl-pyrrolidin-2-one; dichloromethane;