(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-bromo-2-butenamide

Base Information

Chemical Name:(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-bromo-2-butenamide
CAS No.:1363359-87-8
Molecular Formula:C₂₈H₃₀BrClFN₅O₂
Molecular Weight:602.934
Hs Code.:

Synonyms:(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-bromo-2-butenamide

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Chemical Property of (E)-N-(4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-bromo-2-butenamide

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Technology Process of (E)-N-(4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-bromo-2-butenamide

There total 11 articles about (E)-N-(4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-bromo-2-butenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13991-36-1
4-bromocrotonic acid

: 1363359-86-7
N-(4-(3-chloro-4-fluorophenyl))-7-(2-(7-methyl-7-azaspiro[3.5]nonan-2-yl)ethoxy)quinazolin-4,6-diamine

: 1363359-87-8
(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-bromo-2-butenamide

Guidance literature:: 4-bromocrotonic acid; With dicyclohexyl-carbodiimide; In tetrahydrofuran; for 0.5h; Inert atmosphere; Cooling with ice;

N-(4-(3-chloro-4-fluorophenyl))-7-(2-(7-methyl-7-azaspiro[3.5]nonan-2-yl)ethoxy)quinazolin-4,6-diamine; In tetrahydrofuran; N,N-dimethyl-formamide; for 0.666667h; Inert atmosphere;

Reference yield:

: 13991-36-1,20629-35-0
4-bromocrotonic acid

N⁴-(3-chloro-4-fluorophenyl)-7-((7-methyl-7-azaspiro[3.5]non-2-yl)methoxy)quinazolin-4,6-diamine: 1363359-84-5
N⁴-(3-chloro-4-fluorophenyl)-7-((7-methyl-7-azaspiro[3.5]non-2-yl)methoxy)quinazolin-4,6-diamine

: 1363359-87-8
(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-bromo-2-butenamide

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; for 1.16667h; Inert atmosphere; Cooling with ice;

Reference yield:

: 446-32-2
4-fluoroanthranilic acid

: 1363359-87-8
(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-bromo-2-butenamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / 2-methoxy-ethanol / Reflux

2.1: nitric acid; sulfuric acid

3.1: thionyl chloride

4.1: isopropyl alcohol

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere; Cooling with ice

5.2: 20 °C / Inert atmosphere

6.1: acetic acid; iron / ethanol / 12 h / 30 °C

7.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling with ice

7.2: 0.67 h / Inert atmosphere

With thionyl chloride; sulfuric acid; nitric acid; iron; sodium hydride; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; 2-methoxy-ethanol; N,N-dimethyl-formamide; isopropyl alcohol;