(E)-N-(4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-dimethylamino-2-butenamide

Base Information

Chemical Name:(E)-N-(4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-dimethylamino-2-butenamide
CAS No.:1363358-88-6
Molecular Formula:C₃₀H₃₆ClFN₆O₂
Molecular Weight:567.106
Hs Code.:

Synonyms:(E)-N-(4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-dimethylamino-2-butenamide

Suppliers and Price of (E)-N-(4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-dimethylamino-2-butenamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-N-(4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-dimethylamino-2-butenamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-N-(4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-dimethylamino-2-butenamide

There total 12 articles about (E)-N-(4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-dimethylamino-2-butenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1363359-87-8
(E)-N-(4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-bromo-2-butenamide

: 506-59-2
N,N-dimethylammonium chloride

: 1363358-88-6
(E)-N-(4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-dimethylamino-2-butenamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; at 20 ℃; Cooling with ice;

Reference yield:

: 446-32-2
4-fluoroanthranilic acid

: 1363358-88-6
(E)-N-(4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-dimethylamino-2-butenamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid / 2-methoxy-ethanol / Reflux

2.1: nitric acid; sulfuric acid

3.1: thionyl chloride

4.1: isopropyl alcohol

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere; Cooling with ice

5.2: 20 °C / Inert atmosphere

6.1: acetic acid; iron / ethanol / 12 h / 30 °C

7.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling with ice

7.2: 0.67 h / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine / 20 °C / Cooling with ice

With thionyl chloride; sulfuric acid; nitric acid; iron; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; 2-methoxy-ethanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 16499-57-3
7-fluoro-3H-quinazolin-4-one

: 1363358-88-6
(E)-N-(4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)-4-dimethylamino-2-butenamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: nitric acid; sulfuric acid

2.1: thionyl chloride

3.1: isopropyl alcohol

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere; Cooling with ice

4.2: 20 °C / Inert atmosphere

5.1: acetic acid; iron / ethanol / 12 h / 30 °C

6.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling with ice

6.2: 0.67 h / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine / 20 °C / Cooling with ice

With thionyl chloride; sulfuric acid; nitric acid; iron; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;