tert-Butyl-[(3S,4R)-3-(4-methoxy-benzyloxy)-4-methyl-hept-5-ynyloxy]-dimethyl-silane

Base Information

Chemical Name:tert-Butyl-[(3S,4R)-3-(4-methoxy-benzyloxy)-4-methyl-hept-5-ynyloxy]-dimethyl-silane
CAS No.:148933-65-7
Molecular Formula:C₂₂H₃₆O₃Si
Molecular Weight:376.612
Hs Code.:

Synonyms:tert-Butyl-[(3S,4R)-3-(4-methoxy-benzyloxy)-4-methyl-hept-5-ynyloxy]-dimethyl-silane

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Chemical Property of tert-Butyl-[(3S,4R)-3-(4-methoxy-benzyloxy)-4-methyl-hept-5-ynyloxy]-dimethyl-silane

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Technology Process of tert-Butyl-[(3S,4R)-3-(4-methoxy-benzyloxy)-4-methyl-hept-5-ynyloxy]-dimethyl-silane

There total 5 articles about tert-Butyl-[(3S,4R)-3-(4-methoxy-benzyloxy)-4-methyl-hept-5-ynyloxy]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 148933-82-8
tert-Butyl-[(3S,4R)-6,6-dibromo-3-(4-methoxy-benzyloxy)-4-methyl-hex-5-enyloxy]-dimethyl-silane

: 74-88-4
methyl iodide

: 148933-65-7
tert-Butyl-[(3S,4R)-3-(4-methoxy-benzyloxy)-4-methyl-hept-5-ynyloxy]-dimethyl-silane

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 - 0 ℃; for 1h;
DOI:10.1039/c39930000619

Reference yield:

: 89922-82-7
3-(tert-butyldimethylsilanyloxy)propionaldehyde

: 148933-65-7
tert-Butyl-[(3S,4R)-3-(4-methoxy-benzyloxy)-4-methyl-hept-5-ynyloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

2: 90 percent / NaHMDS / tetrahydrofuran; dimethylformamide / 2.5 h / Ambient temperature

3: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, MeOH, pyridine, -78 deg C, 2.) 25 deg C, 16h

4: 1.) Zn, Ph₃P / 1.) CH₂Cl₂, 25 deg C, 24 h, 2.) 25 deg C, 2 h

5: 1.) n-BuLi / 1.) THF, hexane, -78 to -20 deg C; -20 deg C, 1 h, 2.) 0 deg C, 2 h

With n-butyllithium; dimethylsulfide; sodium hexamethyldisilazane; ozone; triphenylphosphine; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 168777-81-9
(3S,4R)-1-[(tert-butyldimethylsilyl)oxy]-4-methylhex-5-en-3-ol

: 148933-65-7
tert-Butyl-[(3S,4R)-3-(4-methoxy-benzyloxy)-4-methyl-hept-5-ynyloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / NaHMDS / tetrahydrofuran; dimethylformamide / 2.5 h / Ambient temperature

2: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, MeOH, pyridine, -78 deg C, 2.) 25 deg C, 16h

3: 1.) Zn, Ph₃P / 1.) CH₂Cl₂, 25 deg C, 24 h, 2.) 25 deg C, 2 h

4: 1.) n-BuLi / 1.) THF, hexane, -78 to -20 deg C; -20 deg C, 1 h, 2.) 0 deg C, 2 h

With n-butyllithium; dimethylsulfide; sodium hexamethyldisilazane; ozone; triphenylphosphine; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;