2'-Benzylsulfanyl-biphenyl-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester

Base Information

• Chemical Name: 2'-Benzylsulfanyl-biphenyl-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester
• CAS No.: 186295-46-5
• Molecular Formula: C₂₄H₁₉NO₄S
• Molecular Weight: 417.485
• Mol file: 186295-46-5.mol

Synonyms:2'-Benzylsulfanyl-biphenyl-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester

Chemical Property of 2'-Benzylsulfanyl-biphenyl-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2'-Benzylsulfanyl-biphenyl-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 2 articles about 2'-Benzylsulfanyl-biphenyl-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 2'-Benzylsulfanyl-biphenyl-2-carboxylic acid (186295-31-8) → 2'-Benzylsulfanyl-biphenyl-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester (186295-46-5)

Guidance literature:

With dicyclohexyl-carbodiimide; In 1,4-dioxane; for 5h; Ambient temperature;

Reference yield:

6H-benzo[c]thiochromen-6-one (4445-36-7) → 2'-Benzylsulfanyl-biphenyl-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester (186295-46-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaBH₄, NaOH / 1.) H₂O, EtOH, reflux, 2 h; 2.) H₂O, EtOH, 0 deg C - RT

2: 93 percent / N,N'-dicyclohexylcarbodiimide / dioxane / 5 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; dicyclohexyl-carbodiimide; In 1,4-dioxane;

Reference yield: 92.0%

2'-Benzylsulfanyl-biphenyl-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester (186295-46-5) → 2'-Benzylsulfanyl-biphenyl-2-carboxylic acid amide (186295-45-4)

Guidance literature:

With ammonia; In dichloromethane; at 0 ℃; for 2h;

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

2'-Benzylsulfanyl-biphenyl-2-carboxylic acid

6H-benzo[c]thiochromen-6-one

Downstream raw materials:

2'-Benzylsulfanyl-biphenyl-2-carboxylic acid amide