Technology Process of 1-ethoxy-2,3-difluoro-4-(4-(methoxymethylene)cyclohexyl)benzene
There total 5 articles about 1-ethoxy-2,3-difluoro-4-(4-(methoxymethylene)cyclohexyl)benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(methoxymethyl)triphenylphosphonium chloride;
With
potassium tert-butylate;
In
tetrahydrofuran;
for 1h;
Inert atmosphere;
Cooling with ice;
4-(2,3-difluoro-4-ethoxyphenyl)-cyclohexanone;
In
tetrahydrofuran;
for 3h;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid; ammonium chloride; sodium hydrogencarbonate / palladium-carbon / toluene; water; tetrahydrofuran; n-hexane-cyclohexane
2: sodium hydrogencarbonate; formic acid / toluene; water
3: potassium tert-butylate / water; tetrahydrofuran
With
formic acid; ammonium chloride; potassium tert-butylate; sodium hydrogencarbonate; toluene-4-sulfonic acid;
palladium-carbon;
In
tetrahydrofuran; n-hexane-cyclohexane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid; ammonium chloride; sodium hydrogencarbonate / palladium-carbon / toluene; water; tetrahydrofuran; n-hexane-cyclohexane
2: sodium hydrogencarbonate; formic acid / toluene; water
3: potassium tert-butylate / water; tetrahydrofuran
With
formic acid; ammonium chloride; potassium tert-butylate; sodium hydrogencarbonate; toluene-4-sulfonic acid;
palladium-carbon;
In
tetrahydrofuran; n-hexane-cyclohexane; water; toluene;
