Chemical Property of Fomepizole
Chemical Property:
- Appearance/Colour:clear colourless to yellowish liquid after melting
- Vapor Pressure:0.0497mmHg at 25°C
- Melting Point:13°C
- Refractive Index:n20/D 1.495(lit.)
- Boiling Point:243.6 °C at 760 mmHg
- PKA:14.95±0.50(Predicted)
- Flash Point:96.1 °C
- PSA：28.68000
- Density:1.062 g/cm3
- LogP:0.71810
- Storage Temp.:2-8°C
- Sensitive.:Hygroscopic
- Solubility.:soluble
- Water Solubility.:soluble
- XLogP3:1.4
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:1
- Rotatable Bond Count:0
- Exact Mass:82.053098200
- Heavy Atom Count:6
- Complexity:44.8
- Purity/Quality:
-
99% *data from raw suppliers
Fomepizole *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22-36/37/38
- Safety Statements:
26-36-24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CNN=C1
- Recent ClinicalTrials:Specified Drug-use Survey of Fomepizole Intravenous Infusion (All-case Surveillance)
- Recent NIPH Clinical Trials:None
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Description
Fomepizole is the first drug indicated as an antidote for ethylene glycol poisoning (it has also shown promise as a treatment for methanol poisoning). Fomepizole is 4-methyl-1H-pyrazole active as a synthetic alcohol dehydrogenase inhibitor, blocking the formation of toxic ethylene glycol metabolites which are responsible for a severe metabolic acidosis and renal failure. In limited human studies, it reversed the toxicity of potentially lethal doses of ethylene glycol. The main urinary metabolite has been reported to be 4-carboxypyrazole by oxidation of the methyl group. Compared with the current treatment (ethanol), the duration of action is longer and the safety is improved, with no toxic effects reported. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes metabolism of ethylene glycol and methanol to toxic metabolites. At 10 μM in monkeys, it can prevent the formation of toxic alcohol metabolites that generate metabolic acidosis. 4-Methylpyrazole is typically used as an antidote for ethylene glycol or methanol poisoning.
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Uses
Useful as an antidote in methanol and ethylene glycol poisoning. Antidote in methanol or ethylene glycol poisoning;Alcohol dehydrogenase inhibitor antidote to ethylene glycol or methanol poisoning Fomepizole (4-Methylpyrazole) can be used as: A reactant to prepare 4-methyl-1-phenyl-1H-pyrazole by reacting with bromobenzene via N-arylation using a copper catalyst. A starting material for the synthesis of 4-methyl-3(5)-nitropyrazole by nitration. A ligand in the preparation of gallium(III) complex of 4-methylpyrazole as potential antitumor and antiviral agent.
