10602-37-6

Basic information

• Product Name: 1,1,3,3-TETRAETHOXY-2-METHYLPROPANE
• Synonyms: 1,1,3,3-TETRAETHOXY-2-METHYLPROPANE;2-Methyl-1,1,3,3-tetraethoxypropane;Propane,1,1,3,3-tetraethoxy-2-methyl-;Einecs 234-225-2;1,1,3,3-Tetramethoxy-2-methyl propane
• CAS NO: 10602-37-6
• Molecular Formula: C₁₂H₂₆O₄
• Molecular Weight: 178.23
• EINECS: 234-225-2
• Product Categories: API intermediates
• Mol File: 10602-37-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 159°C 30mm
• Flash Point: 64°C
• Appearance: /
• Density: 0,92 g/cm3
• Vapor Pressure: 0.00983mmHg at 25°C
• Refractive Index: 1.423
• CAS DataBase Reference: 1,1,3,3-TETRAETHOXY-2-METHYLPROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,3,3-TETRAETHOXY-2-METHYLPROPANE(10602-37-6)
• EPA Substance Registry System: 1,1,3,3-TETRAETHOXY-2-METHYLPROPANE(10602-37-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 16-26-36
• RIDADR: 1993
• Hazardous Substances Data: 10602-37-6(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

1,1,3,3-Tetraethoxy-2-methyl-propane is a useful synthetic intermediate. It used to synthesize various compounds such as Imidazo[1,2-a]pyrimidine, and chlorinated arenes.

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 5243, 1984 DOI: 10.1016/S0040-4039(01)81574-4

InChI:InChI=1/C12H26O4/c1-6-13-11(14-7-2)10(5)12(15-8-3)16-9-4/h10-12H,6-9H2,1-5H3

Upstream product

• 4696-26-8 (E)-1-ethoxyprop-1-ene 
• 122-51-0 orthoformic acid triethyl ester 
• 14036-06-7 diethoxymethyl acetate 
• 4696-25-7 (Z)-1-ethoxyprop-1-ene 
• 14112-68-6 1-chloro-3,3-diethoxy-2-methyl-propene 
• 50300-18-0 (Z)-1-<(trimethylsilyl)oxy>propene 
• 19879-97-1 trimethylsilyl propenyl ether 
• 3249-50-1 1-propenyl acetate 
• 64-17-5 ethanol 
• 14112-78-8 1,3-dichloro-3-ethoxy-2-methyl-propene 
• 928-55-2 ethyl 1-propenyl ether 

Downstream Products

• 16002-19-0 2-methyl-1,3-propanedialdehyde 
• 42588-57-8 3-ethoxymethacrolein 
• 832741-06-7 ethyl 6-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 1335283-56-1 N-((E)-2-methyl-3-(phenylimino)prop-1-enyl)benzenamine hydrochloride 
• 13808-75-8 1-(2,4-dinitrophenyl)-4-methylpyrazole 
• 1030017-78-7 6-methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid 2-chlorophenylamide 
• 1021178-40-4 methyl 3-chloro-2-hydroxy-5-methylbenzoate 
• 7554-65-6 4-methyl-1H-pyrazole 
• 5570-72-9 1-(2-hydroxy-3,5-dimethylphenyl)-1-propanone 
• 1470-57-1 2-hydroxy-5-methylbenzophenone 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 1072-68-0 1,4-dimethyl-1H-pyrazole 
• 14766-43-9 4-methyl-1-phenyl-1H-pyrazole 
• 88848-27-5 1-Methyl-3-[(Z)-2-methyl-3-(1-methyl-2-phenyl-1H-indol-3-yl)-prop-2-en-(E)-ylidene]-2-phenyl-3H-indolium; chloride 

Relevant articles and documents

TOTAL SYNTHESIS OF (+/-)-THIOLACTOMYCIN

We have completed the first total synthesis of (+/-)-thiolactomycin by a five-step procedure in 10percent overall yield starting from ketoester 6.The key step involves addition of dianion 3 to 3-ethoxy-2-methyl-2-propenal.The resulting aldehyde 11 was then converted into (+/-)-thiolactomycin.

ULTRAPURE 4-METHYLPYRAZOLE

Disclosed is an ultrapure 4-methylpyrazole containing less than 0.1% pyrazole and containing less than 10 ppm each of hydrazine and nitrobenzaldehyde. The ultrapure 4-methylpyrazole is prepared by a novel process so that less than 0.01% of ethylvinyl ether is present.

A Concise Synthesis of the Octalactins

The total synthesis of octalactins A and B has been achieved in 15 steps (longest linear sequence) and 10% overall yield from commercially available materials. Key steps include the Paterson-Aldol reaction for the rapid assembly of the carbonate 46, methylenation of 46 and subsequent Claisen rearrangement of the corresponding alkenyl-substituted cyclic ketene acetal to provide the core unsaturated medium-ring lactone 47, and the use of enzyme-mediated acetate deprotection in the presence of a medium-ring lactone.