2-(tert-butoxy)-2-(1,6-dimethyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-yl)acetic acid

Base Information

Chemical Name:2-(tert-butoxy)-2-(1,6-dimethyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-yl)acetic acid
CAS No.:1428794-03-9
Molecular Formula:C₂₂H₂₆N₂O₄
Molecular Weight:382.459
Hs Code.:

Synonyms:2-(tert-butoxy)-2-(1,6-dimethyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-yl)acetic acid

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Chemical Property of 2-(tert-butoxy)-2-(1,6-dimethyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-yl)acetic acid

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Technology Process of 2-(tert-butoxy)-2-(1,6-dimethyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-yl)acetic acid

There total 4 articles about 2-(tert-butoxy)-2-(1,6-dimethyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1428794-64-2
methyl 2-(tert-butoxy)-2-(1,6-dimethyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetate

: 1428794-03-9
2-(tert-butoxy)-2-(1,6-dimethyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-yl)acetic acid

Guidance literature:: methyl 2-(tert-butoxy)-2-(1,6-dimethyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetate; With methanol; lithium hydroxide; In tetrahydrofuran; at 60 ℃; for 4h;

With trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1428794-61-9
methyl 2-hydroxy-2-(6-methyl-7-oxo-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-5-yl)acetate

: 1428794-03-9
2-(tert-butoxy)-2-(1,6-dimethyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / 6 h / 50 °C

2: perchloric acid / 48 h / Cooling with ice

3: lithium hydroxide; methanol / tetrahydrofuran / 4 h / 60 °C

With methanol; perchloric acid; caesium carbonate; lithium hydroxide; In tetrahydrofuran;

Reference yield:

: 1428794-63-1
methyl 2-(1,6-dimethyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-yl)-2-hydroxyacetate

: 1428794-03-9
2-(tert-butoxy)-2-(1,6-dimethyl-7-oxo-4-(p-tolyl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: perchloric acid / 48 h / Cooling with ice

2: lithium hydroxide; methanol / tetrahydrofuran / 4 h / 60 °C

With methanol; perchloric acid; lithium hydroxide; In tetrahydrofuran;