(2R,4S,5S)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-{[3-(1,1-dioxo-1,6-isothiazolidin-2-yl)benzoyl]amino}-2,7-dimethyloctanoic acid

Base Information

Chemical Name:(2R,4S,5S)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-{[3-(1,1-dioxo-1,6-isothiazolidin-2-yl)benzoyl]amino}-2,7-dimethyloctanoic acid
CAS No.:849409-77-4
Molecular Formula:C₂₆H₄₄N₂O₆SSi
Molecular Weight:540.797
Hs Code.:

Synonyms:(2R,4S,5S)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-{[3-(1,1-dioxo-1,6-isothiazolidin-2-yl)benzoyl]amino}-2,7-dimethyloctanoic acid

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Chemical Property of (2R,4S,5S)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-{[3-(1,1-dioxo-1,6-isothiazolidin-2-yl)benzoyl]amino}-2,7-dimethyloctanoic acid

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Technology Process of (2R,4S,5S)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-{[3-(1,1-dioxo-1,6-isothiazolidin-2-yl)benzoyl]amino}-2,7-dimethyloctanoic acid

There total 1 articles about (2R,4S,5S)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-{[3-(1,1-dioxo-1,6-isothiazolidin-2-yl)benzoyl]amino}-2,7-dimethyloctanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 849409-75-2
3-(1,1-dioxo-1,6-isothiazolidin-2-yl)-N-{(1S)-3-methyl-1-[(2R,4R)-4-methyl-5-oxotetrahydro-2-furanyl]butyl}benzamide

: 18162-48-6
tert-butyldimethylsilyl chloride

: 849409-77-4
(2R,4S,5S)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-{[3-(1,1-dioxo-1,6-isothiazolidin-2-yl)benzoyl]amino}-2,7-dimethyloctanoic acid

Guidance literature:: 3-(1,1-dioxo-1,6-isothiazolidin-2-yl)-N-{(1S)-3-methyl-1-[(2R,4R)-4-methyl-5-oxotetrahydro-2-furanyl]butyl}benzamide; With lithium hydroxide; water; In tetrahydrofuran; for 1h;

With water; citric acid;

tert-butyldimethylsilyl chloride; With 1H-imidazole; citric acid; more than 3 stages;

Reference yield: 71.0%

: 849409-78-5
benzyl 4-[({(2S)-2-[(tert-butoxycarbonyl)amino]propanoyl}amino)methyl]benzoate

: 849409-77-4
(2R,4S,5S)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-{[3-(1,1-dioxo-1,6-isothiazolidin-2-yl)benzoyl]amino}-2,7-dimethyloctanoic acid

: 849409-79-6
benzyl 4-[(4S,7R,9S)-9-((1S)-1-{[3-(1,1-dioxo-1,6-isothiazolidin-2-yl)benzoyl]amino}-3-methylbutyl)-4,7,11,11,12,12-hexamethyl-3,6-dioxo-10-oxa-2,5-diaza-11-silatridec-1-yl]benzoate

Guidance literature:: benzyl 4-[({(2S)-2-[(tert-butoxycarbonyl)amino]propanoyl}amino)methyl]benzoate; With hydrogenchloride; water; In ethyl acetate; for 2h;

(2R,4S,5S)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-{[3-(1,1-dioxo-1,6-isothiazolidin-2-yl)benzoyl]amino}-2,7-dimethyloctanoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 4h;