phenylacetic acid 3-(diethylamino)-2-hydroxy-3-oxopropyl ester

Base Information

• Chemical Name: phenylacetic acid 3-(diethylamino)-2-hydroxy-3-oxopropyl ester
• CAS No.: 855526-49-7
• Molecular Formula: C₁₅H₂₁NO₄
• Molecular Weight: 279.336
• Mol file: 855526-49-7.mol

Synonyms:phenylacetic acid 3-(diethylamino)-2-hydroxy-3-oxopropyl ester

Chemical Property of phenylacetic acid 3-(diethylamino)-2-hydroxy-3-oxopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of phenylacetic acid 3-(diethylamino)-2-hydroxy-3-oxopropyl ester

There total 2 articles about phenylacetic acid 3-(diethylamino)-2-hydroxy-3-oxopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

phenylacetyl chloride (103-80-0) + N,N-diethyl-2,3-dihydroxypropanamide (477211-58-8) → phenylacetic acid 3-(diethylamino)-2-hydroxy-3-oxopropyl ester (855526-49-7)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/jo050246s

Reference yield:

N,N-diethyl-2,2-dimethyl-1,3-dioxolane-4-carboxamide (855526-45-3) → phenylacetic acid 3-(diethylamino)-2-hydroxy-3-oxopropyl ester (855526-49-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / acetic acid / H₂O / 1 h / Heating

2: 75 percent / pyridine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 24 h / 20 °C

With pyridine; dmap; acetic acid; In dichloromethane; water;

DOI:10.1021/jo050246s

Reference yield: 68.0%

phenylacetic acid 3-(diethylamino)-2-hydroxy-3-oxopropyl ester (855526-49-7) → phenylacetic acid 3-(diethylamino)-2,3-dioxopropyl ester (497872-20-5)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/jo050246s

upstream raw materials:

phenylacetyl chloride

N,N-diethyl-2,3-dihydroxypropanamide

N,N-diethyl-2,2-dimethyl-1,3-dioxolane-4-carboxamide

Downstream raw materials:

phenylacetic acid 3-(diethylamino)-2,3-dioxopropyl ester

phenyl-acetic acid 1-[ethyl-(2-oxo-propionyl)-amino]-ethyl ester

3-ethyl-2-methyl-5-methylene-oxazolidin-4-one

3-ethyl-5-hydroxy-2,5-dimethyl-oxazolidin-4-one