ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-cyanomethyl-9H-pyrido[3,4-b]indole-1-carboxylate

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Chemical Name:ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-cyanomethyl-9H-pyrido[3,4-b]indole-1-carboxylate
CAS No.:1352835-42-7
Molecular Formula:C₃₁H₂₆N₄O₄
Molecular Weight:518.572
Hs Code.:

Synonyms:ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-cyanomethyl-9H-pyrido[3,4-b]indole-1-carboxylate

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Chemical Property of ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-cyanomethyl-9H-pyrido[3,4-b]indole-1-carboxylate

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Technology Process of ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-cyanomethyl-9H-pyrido[3,4-b]indole-1-carboxylate

There total 7 articles about ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-cyanomethyl-9H-pyrido[3,4-b]indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.6%

: 924-44-7
glyoxylic acid ethyl ester

: 1352835-41-6
benzyl 3-(2-amino-1-(6-cyanomethyl-1H-indol-3-yl)ethyl)-2-methylphenylcarbamate

: 1352835-42-7
ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-cyanomethyl-9H-pyrido[3,4-b]indole-1-carboxylate

Guidance literature:: glyoxylic acid ethyl ester; benzyl 3-(2-amino-1-(6-cyanomethyl-1H-indol-3-yl)ethyl)-2-methylphenylcarbamate; With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; toluene; at 20 ℃; for 48h;

With sodium hydrogencarbonate; In water;

palladium 10% on activated carbon; In xylene; at 125 ℃; for 10h; Inert atmosphere;

Reference yield:

: 69022-35-1
2-methyl-3-amino-benzonitrile

: 1352835-42-7
ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-cyanomethyl-9H-pyrido[3,4-b]indole-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C

2.2: 0.5 h / 20 °C / Cooling with ice

3.1: ammonium acetate; acetic acid / 4.5 h / 90 °C

4.1: water / 24 h / 105 °C

5.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 5 h / 20 °C

6.1: hydrogenchloride / toluene; 1,4-dioxane; tetrahydrofuran / 48 h / 20 °C

6.3: 10 h / 125 °C / Inert atmosphere

With hydrogenchloride; ammonium acetate; diisobutylaluminium hydride; potassium carbonate; ammonium chloride; acetic acid; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene;

Reference yield:

: 71516-35-3
2-methyl-3-nitrobenzonitrile

: 1352835-42-7
ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-cyanomethyl-9H-pyrido[3,4-b]indole-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 2 h / 0 - 20 °C

2.1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

3.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C

3.2: 0.5 h / 20 °C / Cooling with ice

4.1: ammonium acetate; acetic acid / 4.5 h / 90 °C

5.1: water / 24 h / 105 °C

6.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 5 h / 20 °C

7.1: hydrogenchloride / toluene; 1,4-dioxane; tetrahydrofuran / 48 h / 20 °C

7.3: 10 h / 125 °C / Inert atmosphere

With hydrogenchloride; ammonium acetate; diisobutylaluminium hydride; potassium carbonate; ammonium chloride; acetic acid; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene;