1,2,2-trimethyl-4-({1-[3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)piperazine

Base Information

Chemical Name:1,2,2-trimethyl-4-({1-[3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)piperazine
CAS No.:1355004-04-4
Molecular Formula:C₁₆H₂₁F₃N₆
Molecular Weight:354.378
Hs Code.:

Synonyms:1,2,2-trimethyl-4-({1-[3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)piperazine

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Chemical Property of 1,2,2-trimethyl-4-({1-[3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)piperazine

Chemical Property:

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Technology Process of 1,2,2-trimethyl-4-({1-[3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)piperazine

There total 3 articles about 1,2,2-trimethyl-4-({1-[3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 674792-07-5
2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester

: 1355004-04-4
1,2,2-trimethyl-4-({1-[3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / acetonitrile / 0.33 h / 120 °C / Microwave irradiation

2: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1354947-61-7
1,1-dimethylethyl 2,2-dimethyl-4-({1-[3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-1-piperazinecarboxylate

: 1355004-04-4
1,2,2-trimethyl-4-({1-[3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 890095-46-2
5-(chloromethyl)-1-[3-(trifluoromethyl)phenyl]-1H-tetrazole

: 1355004-04-4
1,2,2-trimethyl-4-({1-[3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / acetonitrile / 0.33 h / 120 °C / Microwave irradiation

2: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;