1-Boc-2,2-dimethyl-piperazine

Base Information

• Chemical Name: 1-Boc-2,2-dimethyl-piperazine
• CAS No.: 674792-07-5
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.308
• Hs Code.: 2933599090
• Mol file: 674792-07-5.mol

Synonyms:2,2-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT BUTYL-ESTER;1-BOC-2,2-DIMETHYL-PIPERAZINE;tert-Butyl 2,2-dimethylpiperazine-1-carboxylate;1-Piperazinecarboxylic acid, 2,2-dimethyl-, 1,1-dimethylethyl ester;4-tert-Butoxycarbonyl-3,3-dimethylpiperazine;1-boc-2,2-diMethylpiperazine hcl;1-boc-2,2-diMethylpiperazine hydrochloride

Chemical Property of 1-Boc-2,2-dimethyl-piperazine

Chemical Property:

• Boiling Point: 275.1 °C at 760 mmHg
• PKA: 8.53±0.40(Predicted)
• Flash Point: 120.2 °C
• PSA: 41.57000
• Density: 0.977 g/cm³
• LogP: 1.87200
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl2,2-Dimethylpiperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-2,2-dimethyl-piperazine

There total 4 articles about 1-Boc-2,2-dimethyl-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-benzyl 1-(tert-butyl) 2,2-dimethylpiperazine-1,4-dicarboxylate → 2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (674792-07-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 5h;

Reference yield:

2,2-dimethylpiperazine (84477-72-5) → 2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (674792-07-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 3 h / -78 - 20 °C

2: triethylamine / dichloromethane / 18 h / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h

With palladium 10% on activated carbon; hydrogen; triethylamine; In dichloromethane; ethyl acetate;

Reference yield:

benzyl 3,3-dimethylpiperazine-1-carboxylate → 2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (674792-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 18 h / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h

With palladium 10% on activated carbon; hydrogen; triethylamine; In dichloromethane; ethyl acetate;

upstream raw materials:

2,2-dimethylpiperazine

Downstream raw materials:

tert-butyl 2,2-dimethyl-4-(4-nitrophenyl)piperazine-1-carboxylate

tert-butyl 4-(4-amino-3-fluorobenzoyl)-2,2-dimethylpiperazine-1-carboxylate

4-[4-(4-(ethoxycarbonyl)-1,3-oxazol-5-yl)phenyl]-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester

tert-butyl 2,2-dimethyl-4-[[4-(morpholin-4-yl)-2-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate

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