1-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)-3-(4-(trifluoromethoxy)phenyl)thiourea

Base Information

Chemical Name:1-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)-3-(4-(trifluoromethoxy)phenyl)thiourea
CAS No.:1412891-63-4
Molecular Formula:C₂₄H₂₁F₃N₄O₃S
Molecular Weight:502.517
Hs Code.:

Synonyms:1-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)-3-(4-(trifluoromethoxy)phenyl)thiourea

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Chemical Property of 1-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)-3-(4-(trifluoromethoxy)phenyl)thiourea

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Technology Process of 1-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)-3-(4-(trifluoromethoxy)phenyl)thiourea

There total 7 articles about 1-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)-3-(4-(trifluoromethoxy)phenyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1412891-71-4
(4-(3-aminophenoxy)pyridin-2-yl)(pyrrolidin-1-yl)methanone

: 64285-95-6
1-isothiocyanato-4-(trifluoromethoxy)benzene

: 1412891-63-4
1-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)-3-(4-(trifluoromethoxy)phenyl)thiourea

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2012.09.031

Reference yield:

: 591-27-5
m-Hydroxyaniline

: 1412891-63-4
1-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)-3-(4-(trifluoromethoxy)phenyl)thiourea

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate; potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 - 90 °C / Inert atmosphere

2: dichloromethane / 18 h / 0 - 20 °C

With potassium tert-butylate; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.09.031

Reference yield:

: 260783-12-8
4-chloro-2-pyridinecarboxylic acid pyrrolidine amide

: 1412891-63-4
1-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)-3-(4-(trifluoromethoxy)phenyl)thiourea

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate; potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 - 90 °C / Inert atmosphere

2: dichloromethane / 18 h / 0 - 20 °C

With potassium tert-butylate; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.09.031