N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxypropoxy)phenyl)-2,2-dimethylpropanamide

Base Information

Chemical Name:N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxypropoxy)phenyl)-2,2-dimethylpropanamide
CAS No.:922162-89-8
Molecular Formula:C₂₂H₂₈ClNO₅
Molecular Weight:421.921
Hs Code.:

Synonyms:N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxypropoxy)phenyl)-2,2-dimethylpropanamide

Suppliers and Price of N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxypropoxy)phenyl)-2,2-dimethylpropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxypropoxy)phenyl)-2,2-dimethylpropanamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxypropoxy)phenyl)-2,2-dimethylpropanamide

There total 5 articles about N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxypropoxy)phenyl)-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 922162-88-7
N-[4-chloro-2-(3-hydroxypropoxy)phenyl]-2,2-dimethylpropanamide

: 135-02-4
ortho-anisaldehyde

: 922162-89-8
N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxypropoxy)phenyl)-2,2-dimethylpropanamide

Guidance literature:: N-[4-chloro-2-(3-hydroxypropoxy)phenyl]-2,2-dimethylpropanamide; With sec.-butyllithium; In tetrahydrofuran; hexane; cyclohexane; at -78 - 20 ℃; for 0.5h;

ortho-anisaldehyde; In tetrahydrofuran; hexane; cyclohexane; at -78 - -50 ℃; for 1.5h;

With water; ammonium chloride; In tetrahydrofuran; hexane; cyclohexane; ethyl acetate;
DOI:10.1016/j.bmc.2011.07.007

Reference yield:

: 922162-87-6
N-(2-[3-(benzyloxy)propoxy]-4-chlorophenyl)-2,2-dimethylpropanamide

: 922162-89-8
N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxypropoxy)phenyl)-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / water; ethyl acetate / 7 h / 20 °C

2.1: sec.-butyllithium / tetrahydrofuran; hexane; cyclohexane / 0.5 h / -78 - 20 °C

2.2: 1.5 h / -78 - -50 °C

With palladium 10% on activated carbon; hydrogen; sec.-butyllithium; In tetrahydrofuran; hexane; cyclohexane; water; ethyl acetate;
DOI:10.1016/j.bmc.2011.07.007

Reference yield:

: 3282-30-2
pivaloyl chloride

: 922162-89-8
N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxypropoxy)phenyl)-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / dichloromethane / 1.5 h / 0 - 20 °C

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 2 h / 0 °C

3.1: palladium 10% on activated carbon; hydrogen / water; ethyl acetate / 7 h / 20 °C

4.1: sec.-butyllithium / tetrahydrofuran; hexane; cyclohexane / 0.5 h / -78 - 20 °C

4.2: 1.5 h / -78 - -50 °C

With palladium 10% on activated carbon; hydrogen; sec.-butyllithium; sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; dichloromethane; cyclohexane; water; ethyl acetate; toluene;
DOI:10.1016/j.bmc.2011.07.007