4-((1R,2S)-2-amino-1-hydroxy-2-(4-methyl-2,6,7-trioxabicyclo[2.2.2]octan-1-yl)ethyl)phenol

Base Information

Chemical Name:4-((1R,2S)-2-amino-1-hydroxy-2-(4-methyl-2,6,7-trioxabicyclo[2.2.2]octan-1-yl)ethyl)phenol
CAS No.:1363373-48-1
Molecular Formula:C₁₄H₁₉NO₅
Molecular Weight:281.309
Hs Code.:

Synonyms:4-((1R,2S)-2-amino-1-hydroxy-2-(4-methyl-2,6,7-trioxabicyclo[2.2.2]octan-1-yl)ethyl)phenol

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Chemical Property of 4-((1R,2S)-2-amino-1-hydroxy-2-(4-methyl-2,6,7-trioxabicyclo[2.2.2]octan-1-yl)ethyl)phenol

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Technology Process of 4-((1R,2S)-2-amino-1-hydroxy-2-(4-methyl-2,6,7-trioxabicyclo[2.2.2]octan-1-yl)ethyl)phenol

There total 6 articles about 4-((1R,2S)-2-amino-1-hydroxy-2-(4-methyl-2,6,7-trioxabicyclo[2.2.2]octan-1-yl)ethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1363373-38-9
benzyl ((1S,2R)-2-(4-(benzyloxy)phenyl)-2-hydroxy-1-(4-methyl-2,6,7-trioxabicyclo[2.2.2]octan-1-yl)ethyl)carbamate

: 1363373-48-1
4-((1R,2S)-2-amino-1-hydroxy-2-(4-methyl-2,6,7-trioxabicyclo[2.2.2]octan-1-yl)ethyl)phenol

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 14h;

Reference yield:

: 99314-44-0
(3-methyloxetan-3-yl)methyl 4-methylbenzenesulfonate

: 1363373-48-1
4-((1R,2S)-2-amino-1-hydroxy-2-(4-methyl-2,6,7-trioxabicyclo[2.2.2]octan-1-yl)ethyl)phenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 36 h / 70 °C / Inert atmosphere

2.1: boron trifluoride diethyl etherate / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2.2: 0.5 h

3.1: dichloromethane / -78 °C / Inert atmosphere

3.2: 2.08 h / -78 °C / Inert atmosphere

3.3: 0.67 h / -78 - 0 °C

4.1: dichloromethane; tetrahydrofuran / 1.22 h / 20 °C / Inert atmosphere; Cooling with ice

4.2: 0.25 h / pH 7

5.1: hydrogen / palladium 10% on activated carbon / methanol / 14 h / 20 °C

With boron trifluoride diethyl etherate; hydrogen; tetra-(n-butyl)ammonium iodide; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 206191-42-6
(S)-(3-methyloxetan-3-yl)methyl 2-(((benzyloxy)carbonyl)-amino)-3-hydroxypropanoate

: 1363373-48-1
4-((1R,2S)-2-amino-1-hydroxy-2-(4-methyl-2,6,7-trioxabicyclo[2.2.2]octan-1-yl)ethyl)phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

1.2: 0.5 h

2.1: dichloromethane / -78 °C / Inert atmosphere

2.2: 2.08 h / -78 °C / Inert atmosphere

2.3: 0.67 h / -78 - 0 °C

3.1: dichloromethane; tetrahydrofuran / 1.22 h / 20 °C / Inert atmosphere; Cooling with ice

3.2: 0.25 h / pH 7

4.1: hydrogen / palladium 10% on activated carbon / methanol / 14 h / 20 °C

With boron trifluoride diethyl etherate; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;