3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-2-(4-((4-aminophenyl)buta-1,3-diyn-1-yl)benzamido)-3-hydroxy-3-(4-hydroxyphenyl)propanoate

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Chemical Name:3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-2-(4-((4-aminophenyl)buta-1,3-diyn-1-yl)benzamido)-3-hydroxy-3-(4-hydroxyphenyl)propanoate
CAS No.:1363373-50-5
Molecular Formula:C₃₁H₃₀N₂O₇
Molecular Weight:542.588
Hs Code.:

Synonyms:3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-2-(4-((4-aminophenyl)buta-1,3-diyn-1-yl)benzamido)-3-hydroxy-3-(4-hydroxyphenyl)propanoate

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Chemical Property of 3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-2-(4-((4-aminophenyl)buta-1,3-diyn-1-yl)benzamido)-3-hydroxy-3-(4-hydroxyphenyl)propanoate

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Technology Process of 3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-2-(4-((4-aminophenyl)buta-1,3-diyn-1-yl)benzamido)-3-hydroxy-3-(4-hydroxyphenyl)propanoate

There total 13 articles about 3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-2-(4-((4-aminophenyl)buta-1,3-diyn-1-yl)benzamido)-3-hydroxy-3-(4-hydroxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1363373-49-2
4-((4-aminophenyl)buta-1,3-diyn-1-yl)-N-((1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-(4-methyl-2,6,7-trioxabicyclo[2.2.2]octan-1-yl)ethyl)benzamide

: 1363373-50-5
3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-2-(4-((4-aminophenyl)buta-1,3-diyn-1-yl)benzamido)-3-hydroxy-3-(4-hydroxyphenyl)propanoate

Guidance literature:: 4-((4-aminophenyl)buta-1,3-diyn-1-yl)-N-((1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-(4-methyl-2,6,7-trioxabicyclo[2.2.2]octan-1-yl)ethyl)benzamide; With water; acetic acid; In 1,4-dioxane; at 20 ℃; for 0.5h; Inert atmosphere;

With sodium hydrogencarbonate; In 1,4-dioxane; pH=10;

Reference yield:

: 99314-44-0
(3-methyloxetan-3-yl)methyl 4-methylbenzenesulfonate

: 1363373-50-5
3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-2-(4-((4-aminophenyl)buta-1,3-diyn-1-yl)benzamido)-3-hydroxy-3-(4-hydroxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 36 h / 70 °C / Inert atmosphere

2.1: boron trifluoride diethyl etherate / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2.2: 0.5 h

3.1: dichloromethane / -78 °C / Inert atmosphere

3.2: 2.08 h / -78 °C / Inert atmosphere

3.3: 0.67 h / -78 - 0 °C

4.1: dichloromethane; tetrahydrofuran / 1.22 h / 20 °C / Inert atmosphere; Cooling with ice

4.2: 0.25 h / pH 7

5.1: hydrogen / palladium 10% on activated carbon / methanol / 14 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 25 h / 0 - 20 °C / Inert atmosphere

7.1: water; acetic acid / 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

7.2: pH 10

With boron trifluoride diethyl etherate; water; hydrogen; tetra-(n-butyl)ammonium iodide; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 3143-02-0
3-hydroxymethyl-3-methyloxethane

: 1363373-50-5
3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-2-(4-((4-aminophenyl)buta-1,3-diyn-1-yl)benzamido)-3-hydroxy-3-(4-hydroxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / 1.75 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 36 h / 70 °C / Inert atmosphere

3.1: boron trifluoride diethyl etherate / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

3.2: 0.5 h

4.1: dichloromethane / -78 °C / Inert atmosphere

4.2: 2.08 h / -78 °C / Inert atmosphere

4.3: 0.67 h / -78 - 0 °C

5.1: dichloromethane; tetrahydrofuran / 1.22 h / 20 °C / Inert atmosphere; Cooling with ice

5.2: 0.25 h / pH 7

6.1: hydrogen / palladium 10% on activated carbon / methanol / 14 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 25 h / 0 - 20 °C / Inert atmosphere

8.1: water; acetic acid / 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

8.2: pH 10

With pyridine; boron trifluoride diethyl etherate; water; hydrogen; tetra-(n-butyl)ammonium iodide; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;