2-allyl-2-methylmalononitrile

Base Information

• Chemical Name: 2-allyl-2-methylmalononitrile
• CAS No.: 154657-02-0
• Molecular Formula: C₇H₈N₂
• Molecular Weight: 120.154
• Mol file: 154657-02-0.mol

Synonyms:2-allyl-2-methylmalononitrile

Chemical Property of 2-allyl-2-methylmalononitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-allyl-2-methylmalononitrile

There total 4 articles about 2-allyl-2-methylmalononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-methylmalononitrile (3696-36-4) + allyltributylstanane (24850-33-7) → 2-allyl-2-methylmalononitrile (154657-02-0)

Guidance literature:

With 1,2-bis-(diphenylphosphino)ethane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1039/c39950002013

Reference yield: 74.0%

2-methylmalononitrile (3696-36-4) + allyl bromide (106-95-6) → 2-allyl-2-methylmalononitrile (154657-02-0)

Guidance literature:

2-methylmalononitrile; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; benzene; at 23 ℃; for 0.333333h;

allyl bromide; In N,N-dimethyl-formamide; mineral oil; benzene; at 105 ℃; for 12h; Reflux;

DOI:10.1021/jacs.6b08788

Reference yield: 44.0%

allyltributylstanane (24850-33-7) + methyliodomalononitrile (138976-63-3) → 2-methylmalononitrile (3696-36-4) + 2-allyl-2-methylmalononitrile (154657-02-0)

Guidance literature:

With zinc chloride diethyl ether; In dichloromethane; at -78 ℃;

DOI:10.3987/COM-97-S(N)71

upstream raw materials:

allyltributylstanane

methyliodomalononitrile

2-methylmalononitrile

allyl bromide

Downstream raw materials:

R-(-)-benzyl 2-carbamyl-2-methylpent-4-enoate

(R)-benzyl 2-carbamoyl-2-methyl-7-phenylhept-4-enoate

(S)-2-amino-2-methyl-7-phenylheptanoic acid

(R,E)-6-benzyl 1-ethyl 5-carbamoyl-5-methylhex-2-enedioate